Gökçe Çokal Burcu, Yurtdaş Mustafa, Keskin Güler Selda, Güneş Hafize Nalan, Ataç Uçar Ceyla, Aytaç Bilal, Durak Zahide Esra, Yoldaş Tahir Kurtuluş, Durak İlker, Çubukçu Hikmet Can
Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey.
Turkish Ministry of Health, Directorate of Health Services, Ankara, Turkey.
Neurol Sci. 2017 Mar;38(3):425-431. doi: 10.1007/s10072-016-2782-8. Epub 2016 Nov 30.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Oxidative stress has been hypothesized to play a major role in the development of PD in various studies. This study assessed to investigate oxidative and anti-oxidative status in PD patients. We evaluated oxidant/antioxidant status by measuring serum malondialdehyde (MDA) levels, xanthine oxidase (XO) activities, and activities of antioxidant enzymes, namely, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD). The study included 29 patients with PD and 32 healthy subjects as controls. Comparison of oxidative parameters in the patient and control groups revealed significantly higher GSH-Px and XO activities in the patient group. Serum MDA and SOD activities in PD patients were not significantly different from the controls. MDA was negatively correlated with duration of the PD and positively with age of onset. There was a negative correlation between SOD and Hoehn and Yahr (H&Y) stage. According to these results, we suggest that oxidative stress may contribute to the development of PD.
帕金森病（PD）是一种进行性神经退行性疾病，其特征是黑质致密部（SNpc）中的多巴胺能（DA）神经元丧失。在各种研究中，氧化应激被认为在PD的发展中起主要作用。本研究旨在评估PD患者的氧化和抗氧化状态。我们通过测量血清丙二醛（MDA）水平、黄嘌呤氧化酶（XO）活性以及抗氧化酶即谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）的活性来评估氧化/抗氧化状态。该研究纳入了29例PD患者和32例健康受试者作为对照。患者组和对照组氧化参数的比较显示，患者组的GSH-Px和XO活性显著更高。PD患者的血清MDA和SOD活性与对照组无显著差异。MDA与PD病程呈负相关，与发病年龄呈正相关。SOD与霍恩和雅尔（H&Y）分期呈负相关。根据这些结果，我们认为氧化应激可能有助于PD的发展。
