Pietramaggiori G, Scherer S, Orgill D P
Plastic and Reconstructive Surgery, University Hospital of Lausanne, Lausanne, Switzerland.
Methods Mol Biol. 2013;1037:245-54. doi: 10.1007/978-1-62703-505-7_13.
As in cancer biology, in wound healing there is a need for objective staging systems to decide for the best treatment and predictors of outcome. We developed in the diabetic (db/db) wound healing model, a staging system, the "wound watch," based on the quantification of angiogenesis and cell proliferation in open wounds. In chronic wounds, there is often a lack of cellular proliferation and angiogenesis that leads to impaired healing. The wound watch addresses this by quantifying the proliferative phase of wound healing in two dimensions (cellular division and angiogenesis). The results are plotted in a two-dimensional graph to monitor the course of healing and compare the response to different treatments.
与癌症生物学一样，在伤口愈合中，需要客观的分期系统来决定最佳治疗方案和预后预测指标。我们在糖尿病（db/db）伤口愈合模型中开发了一种分期系统，即“伤口观察”，该系统基于对开放性伤口中血管生成和细胞增殖的量化。在慢性伤口中，通常存在细胞增殖和血管生成不足的情况，这会导致愈合受损。“伤口观察”通过在两个维度（细胞分裂和血管生成）上量化伤口愈合的增殖阶段来解决这一问题。结果绘制在二维图中，以监测愈合过程并比较对不同治疗的反应。
