心肌梗死后心脏伤口愈合：一种针对左心室细胞外基质重塑的新方法。
Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle.
作者信息
Zamilpa Rogelio, Zhang Jianhua, Chiao Ying Ann, de Castro Brás Lisandra E, Halade Ganesh V, Ma Yonggang, Hacker Sander O, Lindsey Merry L
机构信息
Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, Barshop Institute of Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.
出版信息
Methods Mol Biol. 2013;1037:313-24. doi: 10.1007/978-1-62703-505-7_18.
Abstract
Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.
摘要
心肌梗死（MI）是全球范围内主要的死亡原因。永久性结扎左冠状动脉前降支（LAD）是研究小鼠心肌梗死后效应常用的手术模型。LAD闭塞会引发强烈的伤口愈合反应，其中包括细胞外基质（ECM）重塑。本章提供了关于永久性结扎LAD手术过程的详细指南。此外，我们描述了一种富集心脏组织中ECM的原型方法，该方法能使人们专注于小鼠手术诱导心肌梗死后左心室的ECM重塑。
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Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1418-26. doi: 10.1152/ajpheart.01002.2010. Epub 2011 Feb 4.
2
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Cardiovasc Ther. 2012 Feb;30(1):31-41. doi: 10.1111/j.1755-5922.2010.00207.x. Epub 2010 Jul 14.
3
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