Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark; Disease Systems Immunology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Matrix Biol. 2019 Jan;75-76:43-57. doi: 10.1016/j.matbio.2017.12.001. Epub 2017 Dec 14.
Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure. This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes.
心血管疾病（CVD）是工业化国家中最常见的死亡原因，心肌梗死（MI）是一种主要的 CVD，具有显著的发病率和死亡率。MI 后，左心室（LV）对缺血发生伤口愈合反应，导致细胞外基质（ECM）瘢痕形成以替代坏死的心肌细胞。虽然 MI 后 ECM 的积累被称为心脏纤维化，但这是一个通用术语，并不能区分在梗死区域发生的 ECM 积累以形成对维持左心室（LV）壁完整性结构上必需的瘢痕，以及增加 LV 壁僵硬以加剧扩张并刺激进展为心力衰竭的 ECM 积累。这篇综述重点介绍了 MI 后 LV ECM 重塑，针对 ECM 生物标志物的讨论可能对预测 MI 结局有用。
