Chen T F, Lin S G, Chen L X, Jiang G F, Liang Z Y, Yang M, Qian Y Z, Xie Y A
Division of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou, China.
Zhongguo Yao Li Xue Bao. 1990 Jan;11(1):42-4.
Sprague-Dawley rats were given ig tetramethylpyrazine phosphate (TMP) 5 mg/kg with or without previous borneol 5 mg/kg. The plasma TMP concentrations were analysed by GC method, and the data were treated by NONLIN program. The Cmax were 931 and 562 ng/ml, respectively, (P less than 0.01); while the AUC were 68,849 and 37,174, respectively, (P less than 0.05). It is suggested that the borneol enhances the absorption of the TMP but not in elimination.
给Sprague-Dawley大鼠灌胃磷酸川芎嗪（TMP）5mg/kg，灌胃前给予或不给予冰片5mg/kg。采用气相色谱法分析血浆中TMP浓度，并用NONLIN程序处理数据。Cmax分别为931和562ng/ml（P<0.01）；而AUC分别为68849和37174（P<0.05）。提示冰片可促进TMP的吸收，但不影响其消除。
