毛囊信号网络：以真皮乳头为中心的方法。
Hair follicle signaling networks: a dermal papilla-centric approach.
机构信息
Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
出版信息
J Invest Dermatol. 2013 Oct;133(10):2306-2308. doi: 10.1038/jid.2013.262.
Abstract
Functional testing of dermal papilla (DP) signaling inputs into hair follicle (HF) morphogenesis and regeneration is becoming possible with the advent of new Cre lines. Targeted deletion of the signature genes in early DP precursors has revealed significant signaling redundancy during HF morphogenesis. Furthermore, the DP lineage commitment program can be exploited for generating highly inductive DP cells to be used in HF bioengineering assays.
摘要
随着新 Cre 系的出现，真皮乳头 (DP) 信号输入到毛囊 (HF) 形态发生和再生的功能测试成为可能。早期 DP 前体细胞中特征基因的靶向缺失揭示了 HF 形态发生过程中信号的显著冗余性。此外，DP 谱系决定程序可用于产生高度诱导的 DP 细胞，用于 HF 生物工程测定。
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本文引用的文献
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J Invest Dermatol. 2013 Oct;133(10):2332-2339. doi: 10.1038/jid.2013.140. Epub 2013 Mar 14.
2
Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.Fgf20 调控发育毛囊中初级和次级真皮凝聚的形成。
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3
Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.表皮 Wnt 通过协调表皮和真皮之间的动态信号串扰来控制毛囊的诱导。
J Invest Dermatol. 2013 Apr;133(4):890-8. doi: 10.1038/jid.2012.407. Epub 2012 Nov 29.
4
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Dev Cell. 2012 Nov 13;23(5):981-94. doi: 10.1016/j.devcel.2012.10.013.
5
Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation.Tbx18 靶向真皮凝聚物，用于标记、分离和基因敲除胚胎毛囊形成过程中的基因。
J Invest Dermatol. 2013 Feb;133(2):344-53. doi: 10.1038/jid.2012.329. Epub 2012 Sep 20.
6
Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop.Shh 通过 Noggin-Shh 调节环路维持真皮乳头的身份和毛发形态发生。
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7
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Dev Cell. 2010 Apr 20;18(4):633-42. doi: 10.1016/j.devcel.2010.01.016.
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Cell Stem Cell. 2009 Feb 6;4(2):155-69. doi: 10.1016/j.stem.2008.12.009.
10
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