Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
J Invest Dermatol. 2013 Oct;133(10):2306-2308. doi: 10.1038/jid.2013.262.
Functional testing of dermal papilla (DP) signaling inputs into hair follicle (HF) morphogenesis and regeneration is becoming possible with the advent of new Cre lines. Targeted deletion of the signature genes in early DP precursors has revealed significant signaling redundancy during HF morphogenesis. Furthermore, the DP lineage commitment program can be exploited for generating highly inductive DP cells to be used in HF bioengineering assays.
随着新 Cre 系的出现，真皮乳头 (DP) 信号输入到毛囊 (HF) 形态发生和再生的功能测试成为可能。早期 DP 前体细胞中特征基因的靶向缺失揭示了 HF 形态发生过程中信号的显著冗余性。此外，DP 谱系决定程序可用于产生高度诱导的 DP 细胞，用于 HF 生物工程测定。
