Gan V N, Murphy T V
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas.
Am J Dis Child. 1990 Oct;144(10):1130-4. doi: 10.1001/archpedi.1990.02150340076027.
Before the whole-cell pertussis vaccine was available, Bordetella pertussis infections were an important cause of morbidity and mortality in infants. To determine the extent of continuing morbidity in an era of vaccination, a retrospective review was conducted of the records of neonates and infants hospitalized with pertussis infection at Parkland Memorial Hospital and Children's Medical Center, Dallas, Tex. During the 20 years from 1967 through 1986, 182 patients were younger than 24 months. Among 176 patients whose immunization history was recorded, 89% had received fewer than two doses of pertussis vaccine. The mean hospital stay was 7.4 days (range, 1 to 69 days). A convulsion occurred in 11 patients (6%). Apnea was reported in 45 patients (25%) and observed in the hospital in 26 (14%). Nine patients (5%) received mechanical ventilatory therapy. Intensive care monitoring was required in 18 patients (10%). Three (1.6%) died, all with secondary bacterial pneumonia. This hospital-based population indicates that pertussis continues to be a cause of serious morbidity and mortality in infants.
在全细胞百日咳疫苗问世之前，百日咳博德特氏菌感染是婴儿发病和死亡的重要原因。为了确定疫苗接种时代持续性发病的程度，对德克萨斯州达拉斯帕克兰纪念医院和儿童医疗中心因百日咳感染住院的新生儿和婴儿记录进行了回顾性研究。在1967年至1986年的20年间，182例患者年龄小于24个月。在记录了免疫史的176例患者中，89%接种的百日咳疫苗少于两剂。平均住院时间为7.4天（范围1至69天）。11例患者（6%）发生惊厥。45例患者（25%）报告有呼吸暂停，其中26例（14%）在医院观察到。9例患者（5%）接受了机械通气治疗。18例患者（10%）需要重症监护监测。3例（1.6%）死亡，均死于继发性细菌性肺炎。基于该医院的数据表明，百日咳仍是婴儿严重发病和死亡的一个原因。
