论“HLA-C 表达水平对 HIV 控制的影响”。

Comment on "Influence of HLA-C expression level on HIV control".

机构信息

Istituto Nazionale Tumori Regina Elena, Via delle Messi d'Oro 156, 00158 Roma, Italy.

出版信息

Science. 2013 Sep 13;341(6151):1175. doi: 10.1126/science.1241266.

Abstract

Apps et al. (Reports, 5 April 2013, p. 87) found that high human leukocyte antigen C (HLA-C) expression favors HIV-1 control. However, as noted here, HLA-C was assessed with a monoclonal antibody (DT9) that cross-reacts with HLA-E. In the context of the available evidence, this is consistent with the idea that the two leukocyte antigens collaborate to keep the HIV-1 virus at bay.

摘要

Apps 等人（报道，2013 年 4 月 5 日，第 87 页）发现高人类白细胞抗原 C（HLA-C）表达有利于 HIV-1 的控制。然而，正如这里所指出的，HLA-C 是用一种与 HLA-E 发生交叉反应的单克隆抗体（DT9）来评估的。在现有证据的背景下，这与两种白细胞抗原协同作用以阻止 HIV-1 病毒的观点是一致的。