关于“人类白细胞抗原 C 表达水平对 HIV 控制的影响”的评论的回复。
Response to Comment on "Influence of HLA-C expression level on HIV control".
机构信息
Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
出版信息
Science. 2013 Sep 13;341(6151):1175. doi: 10.1126/science.1241854.
Abstract
Lo Monaco et al. propose that human leukocyte antigen E (HLA-E) and HLA-C expression levels both contribute to HIV control. The minimal, flat level of cell surface HLA-E detectable by staining with available HLA-E-specific antibodies questions a role for differential HLA-E expression in determining HIV control. Evidence remains far stronger that HLA-C expression levels as detected by the DT9 antibody specifically affect HIV control.
摘要
洛·莫纳科等人提出，人类白细胞抗原 E（HLA-E）和 HLA-C 的表达水平均有助于控制 HIV。现有的 HLA-E 特异性抗体可检测到 HLA-E 的表达水平非常低且平坦，这对 HLA-E 表达差异在决定 HIV 控制中的作用提出了质疑。有强有力的证据表明，DT9 抗体检测到的 HLA-C 表达水平确实会影响 HIV 的控制。
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