Cancer and Inflammation Program, Laboratory of Experimental Immunology, Science Applications International Corporation Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Science. 2013 Sep 13;341(6151):1175. doi: 10.1126/science.1241854.
Lo Monaco et al. propose that human leukocyte antigen E (HLA-E) and HLA-C expression levels both contribute to HIV control. The minimal, flat level of cell surface HLA-E detectable by staining with available HLA-E-specific antibodies questions a role for differential HLA-E expression in determining HIV control. Evidence remains far stronger that HLA-C expression levels as detected by the DT9 antibody specifically affect HIV control.
洛·莫纳科等人提出,人类白细胞抗原 E(HLA-E)和 HLA-C 的表达水平均有助于控制 HIV。现有的 HLA-E 特异性抗体可检测到 HLA-E 的表达水平非常低且平坦,这对 HLA-E 表达差异在决定 HIV 控制中的作用提出了质疑。有强有力的证据表明,DT9 抗体检测到的 HLA-C 表达水平确实会影响 HIV 的控制。