重新评估人类白细胞抗原 C 基因上游 35 千碱基内的 HIV-1 保护单核苷酸多态性与表面 HLA-C 表达之间的关系。
Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.
机构信息
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.
出版信息
J Virol. 2011 Apr;85(7):3367-74. doi: 10.1128/JVI.02276-10. Epub 2011 Jan 19.
Abstract
Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles.
摘要
先前的研究发现，HLA-C 基因座上游 35kb 处的单核苷酸多态性（-35 SNP）、HLA-C 表达与 HIV-1 设定点病毒载量之间存在关联。我们表明，-35 SNP 基因型之间 HLA-C 表达的差异主要归因于 HLA-Cw7 单一等位基因产物的极低表达，HLA-Cw7 是一种常见的 HLA 类型。我们认为，-35 SNP 与 HIV-1 载量的关联表现为该多态性与有利和不利的 HLA-C 和 -B 等位基因的连锁不平衡的结果。
相似文献
1
Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.
J Virol. 2011 Apr;85(7):3367-74. doi: 10.1128/JVI.02276-10. Epub 2011 Jan 19.
2
HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.
PLoS One. 2008;3(11):e3636. doi: 10.1371/journal.pone.0003636. Epub 2008 Nov 4.
3
Genetic variability in markers of HLA-C expression in two diverse South African populations.
PLoS One. 2013 Jul 5;8(7):e67780. doi: 10.1371/journal.pone.0067780. Print 2013.
4
HLA-C Single Nucleotide Polymorphism Associated with Increased Viral Load Level in HIV-1 Infected Individuals from Northeast Brazil.
Curr HIV Res. 2017;15(4):266-272. doi: 10.2174/1570162X15666170511141741.
5
High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism.
J Immunol. 2012 May 1;188(9):4663-70. doi: 10.4049/jimmunol.1103472. Epub 2012 Apr 2.
6
Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.
J Virol. 2018 Sep 12;92(19). doi: 10.1128/JVI.00811-18. Print 2018 Oct 1.
7
Differential microRNA regulation of HLA-C expression and its association with HIV control.
Nature. 2011 Apr 28;472(7344):495-8. doi: 10.1038/nature09914. Epub 2011 Apr 17.
8
The emerging role of HLA-C in HIV-1 infection.
Immunology. 2011 Oct;134(2):116-22. doi: 10.1111/j.1365-2567.2011.03474.x.
9
Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.
Hum Genet. 2014 Sep;133(9):1187-97. doi: 10.1007/s00439-014-1465-x. Epub 2014 Jun 27.
10
Host determinants of HIV-1 control in African Americans.
J Infect Dis. 2010 Apr 15;201(8):1141-9. doi: 10.1086/651382.
引用本文的文献
1
The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E.
Front Immunol. 2024 Mar 20;15:1329032. doi: 10.3389/fimmu.2024.1329032. eCollection 2024.
2
Instability of the HLA-E peptidome of HIV presents a major barrier to therapeutic targeting.
Mol Ther. 2024 Mar 6;32(3):678-688. doi: 10.1016/j.ymthe.2024.01.010. Epub 2024 Jan 12.
3
Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control.
Front Immunol. 2022 May 20;13:879124. doi: 10.3389/fimmu.2022.879124. eCollection 2022.
4
Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1.
Viruses. 2021 Feb 22;13(2):344. doi: 10.3390/v13020344.
5
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.
J Infect Dis. 2021 Jul 2;224(1):175-183. doi: 10.1093/infdis/jiaa698.
6
Polymorphism at rs9264942 is associated with HLA-C expression and inflammatory bowel disease in the Japanese.
Sci Rep. 2020 Jul 24;10(1):12424. doi: 10.1038/s41598-020-69370-8.
7
Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin.
Front Immunol. 2020 Feb 18;11:156. doi: 10.3389/fimmu.2020.00156. eCollection 2020.
8
Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection.
Front Immunol. 2018 Nov 26;9:2735. doi: 10.3389/fimmu.2018.02735. eCollection 2018.
9
Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS.
J Ophthalmol. 2018 Sep 2;2018:3830104. doi: 10.1155/2018/3830104. eCollection 2018.
10
An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.
J Immunol Res. 2018 Feb 25;2018:3174868. doi: 10.1155/2018/3174868. eCollection 2018.
本文引用的文献
1
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Science. 2010 Dec 10;330(6010):1551-7. doi: 10.1126/science.1195271. Epub 2010 Nov 4.
2
Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
J Virol. 2010 Oct;84(19):9879-88. doi: 10.1128/JVI.00320-10. Epub 2010 Jul 21.
3
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.
Nature. 2010 May 20;465(7296):350-4. doi: 10.1038/nature08997. Epub 2010 May 5.
4
Host determinants of HIV-1 control in African Americans.
J Infect Dis. 2010 Apr 15;201(8):1141-9. doi: 10.1086/651382.
5
Rare variants create synthetic genome-wide associations.
PLoS Biol. 2010 Jan 26;8(1):e1000294. doi: 10.1371/journal.pbio.1000294.
6
Common genetic variation and the control of HIV-1 in humans.
PLoS Genet. 2009 Dec;5(12):e1000791. doi: 10.1371/journal.pgen.1000791. Epub 2009 Dec 24.
7
The immune response during acute HIV-1 infection: clues for vaccine development.
Nat Rev Immunol. 2010 Jan;10(1):11-23. doi: 10.1038/nri2674. Epub 2009 Dec 11.
8
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
Nat Genet. 2009 Dec;41(12):1290-4. doi: 10.1038/ng.486.
9
The HLA-B/-C haplotype block contains major determinants for host control of HIV.
Genes Immun. 2009 Dec;10(8):673-7. doi: 10.1038/gene.2009.58. Epub 2009 Aug 20.
10
Common genetic variation and human traits.
N Engl J Med. 2009 Apr 23;360(17):1696-8. doi: 10.1056/NEJMp0806284. Epub 2009 Apr 15.
Zotero 插件