真菌细胞壁的糖缀合物和多糖与免疫系统的激活。
Glycoconjugates and polysaccharides of fungal cell wall and activation of immune system.
机构信息
Instituto de Ciências Biomédicas, Departamento de Microbiologia, Universidade de São Paulo , São Paulo, SP , Brasil;
出版信息
Braz J Microbiol. 2008 Apr;39(2):195-208. doi: 10.1590/S1517-83822008000200001. Epub 2008 Jun 1.
Abstract
Glycoproteins, glycosphingolipids and polysaccharides exposed at the most external layers of the wall are involved in several types of interactions of fungal cells with the exocellular environment. These molecules are fundamental building blocks of organisms, contributing to the structure, integrity, cell growth, differentiation and signaling. Several of them are immunologically active compounds with potential as regulators of pathogenesis and the immune response of the host. Some of these structures can be specifically recognized by antibodies from patients' sera, suggesting that they can be also useful in the diagnosis of fungal infections.
摘要
糖蛋白、糖脂和多糖暴露在细胞壁的最外层，参与真菌细胞与细胞外环境的多种相互作用。这些分子是生物体的基本组成部分，有助于结构、完整性、细胞生长、分化和信号传递。其中一些是具有免疫活性的化合物，具有作为发病机制和宿主免疫反应调节剂的潜力。这些结构中的一些可以被患者血清中的抗体特异性识别，这表明它们也可用于真菌感染的诊断。
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2
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