Pediatrics Infectious Diseases Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Braz J Microbiol. 2012 Apr;43(2):766-9. doi: 10.1590/S1517-83822012000200041. Epub 2012 Jun 1.
Emerging antimicrobial resistance rates and Extended-spectrum beta-lactamase producing Escherichia coli recovered from urinary tract infections (UTI) is an increasing problem in specific regions, limiting therapeutic options. One hundred E. coli isolates causing UTI in patients with age from 2 months to 12 years admitted at CMC in the period of April 2009 to March 2010 were tested for antibiotic susceptibility using the disk diffusion method. Surprisingly high resistance rates were recorded for E. coli against TMP/SMX (84%), cefalotin (66%), cefuroxime (50%), cefixime (50%) and ceftriaxone (45%). Antimicrobial susceptibility of E. coli isolates was followed by meropenem (98%), amikacin (95%), nitrofurantoin (91%) and gentamicin (68%). Extended spectrum beta-lactamase production, was observed in 32% of community and 42% of nosocomial isolates. The results of this study and numerous observations regarding the increasing resistance to these antibiotics, in several countries, emphasize the need for local population-specific surveillance for guiding empirical therapy for UTI in children.
从尿路感染（UTI）患者中分离出的具有新兴抗药性的大肠杆菌和产生超广谱β-内酰胺酶的大肠杆菌在特定地区是一个日益严重的问题，这限制了治疗选择。2009 年 4 月至 2010 年 3 月期间，在 CMC 住院的年龄在 2 个月至 12 岁的患者中，有 100 株引起 UTI 的大肠杆菌分离株使用纸片扩散法进行了抗生素敏感性测试。令人惊讶的是，大肠杆菌对 TMP/SMX（84%）、头孢菌素（66%）、头孢呋辛（50%）、头孢克肟（50%）和头孢曲松（45%）的耐药率很高。大肠杆菌分离株的抗菌药物敏感性依次为美罗培南（98%）、阿米卡星（95%）、呋喃妥因（91%）和庆大霉素（68%）。在 32%的社区分离株和 42%的医院分离株中观察到了超广谱β-内酰胺酶的产生。这项研究的结果以及在许多国家对抗生素日益增加的耐药性的观察结果强调了需要针对当地人群进行特定的监测，以指导儿童 UTI 的经验性治疗。
