Brzozowska Maria, Karowicz-Bilińska Agata
Klinika Patologii Ciazy, I Katedra Ginekologii i Poloznictwa UM w Łodzi.
Ginekol Pol. 2013 Jun;84(6):456-60. doi: 10.17772/gp/1604.
Vitamin D deficiency connected with insufficient production in the skin and limited alimentation delivery disrupts the function of all systems of the body and increases the risk of chronic diseases. Many studies have reported associations between low serum 25-hydroxyvitamin D [25(OH)D] level and symptoms of the polycystic ovary syndrome (PCOS) - insulin resistance, hirsutism, and infertility associated with both, ovulatory disorders and abnormal endometrial receptivity. The beneficial effects of vitamin D supplementation on insulin resistance, ovarian follicles maturation, ovulation and menstrual regularity were confirmed. Due to limited evidence, the additional randomized trials are required to establish the correct dose of vitamin D and confirm the effectiveness of vitamin D treatment in PCOS disorders. However; it seems evident that correct supplementation of vitamin D is beneficial in the management of women with PCOS and low 25(OH)D serum levels, and that it could be helpful in improving the effects of PCOS treatment.
维生素D缺乏与皮肤中生成不足以及膳食摄入受限有关，会扰乱身体所有系统的功能，并增加患慢性病的风险。许多研究报告了低血清25-羟基维生素D [25(OH)D] 水平与多囊卵巢综合征（PCOS）症状之间的关联——胰岛素抵抗、多毛症以及与排卵障碍和子宫内膜容受性异常相关的不孕症。补充维生素D对胰岛素抵抗、卵巢卵泡成熟、排卵和月经规律的有益作用已得到证实。由于证据有限，需要更多随机试验来确定维生素D的正确剂量，并证实维生素D治疗PCOS疾病的有效性。然而，显然正确补充维生素D对管理血清25(OH)D水平低的PCOS女性有益，并且可能有助于改善PCOS治疗效果。
