Francis G L, Hoffman W H, Gala R R, McPherson J C, Zadinsky J
Department of Pediatrics, Eisenhower Army Medical Center, Fort Gordon, GA 30905.
Ann Clin Lab Sci. 1990 Jul-Aug;20(4):239-44.
The present study was performed to determine if any hormone measured in cord blood correlates with the size of the neonatal breast or the presence of galactorrhea. A total of 144 term newborn infants were examined. Estradiol (E2), progesterone (P), testosterone (T), and thyrotropin (TSH) were determined by radioimmunoassay (RIA), and prolactin (PRL) was determined by both RIA and biological activity (BA). The female breast (8.5 +/- 2.0 mm) was found to be larger than that of the male (7.8 +/- 2.1 mm, p less than 0.05). The only hormonal difference between sexes was a higher T level in the male infants (8.0 +/- 3.0 nmol per L vs. 5.5 +/- 1.9 nmol per L, p = 0.002). None of the other hormones measured by RIA correlated with the size of the neonatal breast or the presence of galactorrhea. The BA of PRL was widely variable compared to the PRL RIA but also failed to correlate with neonatal breast size or galactorrhea. This study suggests that T might be one factor in determining the size of the neonatal breast.
本研究旨在确定脐带血中检测的任何激素是否与新生儿乳房大小或溢乳情况相关。共检查了144名足月儿。通过放射免疫分析（RIA）测定雌二醇（E2）、孕酮（P）、睾酮（T）和促甲状腺激素（TSH），并通过RIA和生物活性（BA）测定催乳素（PRL）。发现女性乳房（8.5±2.0毫米）大于男性乳房（7.8±2.1毫米，p<0.05）。两性之间唯一的激素差异是男婴的T水平较高（8.0±3.0纳摩尔/升对5.5±1.9纳摩尔/升，p = 0.002）。通过RIA检测的其他激素均与新生儿乳房大小或溢乳情况无关。与PRL RIA相比，PRL的BA差异很大，但也与新生儿乳房大小或溢乳无关。本研究表明，T可能是决定新生儿乳房大小的一个因素。
