Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India.
Mini Rev Med Chem. 2013 Oct;13(12):1812-35. doi: 10.2174/13895575113136660091.
In the last few decades, a lot of work has been done on heterocycles, especially the imidazole ring, to obtain a scaffold with potential pharmacological properties such as antibacterial, antifungal, anticancer, antiviral, antidiabetic and others, with lesser side effects. The search for new biologically active imidazoles continues to be an interesting area of investigation in medicinal chemistry. The present paper aims to bring together and discuss the wealth of information on antibacterial profile of imidazoles. So it can be employed for future development to obtain new potent drug molecules.
在过去的几十年中,人们对杂环化合物进行了大量的研究,特别是咪唑环,以获得具有潜在药理活性的支架,如抗菌、抗真菌、抗癌、抗病毒、抗糖尿病等,副作用较小。寻找新的具有生物活性的咪唑类化合物仍然是药物化学中一个有趣的研究领域。本文旨在汇集和讨论有关咪唑类化合物抗菌特性的丰富信息。因此,它可以被用于未来的开发,以获得新的有效药物分子。