Li Shu-Rui, Tan Yi-Min, Zhang Ling, Zhou Cheng-He
Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
School of Chemical Technology, Shijiazhuang University, Shijiazhuang 050035, China.
Pharmaceutics. 2023 Apr 27;15(5):1348. doi: 10.3390/pharmaceutics15051348.
The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.
富含电子的五元芳香氮杂环咪唑含有两个氮原子，是广泛存在于大量生物分子和药物中的重要功能片段；其独特结构有利于通过非共价相互作用轻松与各种无机或有机离子及分子结合，形成具有广泛药用潜力的多种超分子复合物，鉴于基于咪唑的超分子复合物在可能的药用应用方面的贡献越来越大，正受到越来越多的关注。这项工作对基于咪唑的超分子复合物的药物研究进行了系统而全面的深入探讨，包括抗癌、抗菌、抗真菌、抗寄生虫、抗糖尿病、抗高血压和抗炎等方面，以及离子受体、成像剂和病理探针。还展望了基于咪唑的超分子药物化学在不久的将来可预见研究的新趋势。希望这项工作为基于咪唑的药物分子和超分子药物制剂以及更有效的诊断剂和病理探针的合理设计提供有益帮助。
