Krivosic-Horber R, Adnet P, Krivosic I, Reyford H
Département d'Anesthésie-Réanimation I, Hôpital B, CHR, Lille.
Arch Fr Pediatr. 1990 Jun-Jul;47(6):421-4.
The realisation and reliability of the halothane-caffeine contracture tests in children to detect the susceptibility to malignant hyperthermia (MH) is still controversial. The present study concerned 26 children aged 2 to 13 years, (mean 9.5 +/- 1.3 years) who were tested either because of a personal symptomatology (14 cases) or as a member of a susceptible MH family (12 cases). Half of the children had a positive test (MHS and MHE) as is found in adults. Furthermore comparison of threshold concentrations of halothane and caffeine as well as the 32 nmol caffeine-induced contractures dit not show significant differences related to age. These results support the possibility to perform under good conditions and with good reliability the diagnostic test of susceptibility to malignant hyperthermia in children from 2 years on.
氟烷-咖啡因挛缩试验在儿童中用于检测恶性高热（MH）易感性的可行性和可靠性仍存在争议。本研究涉及26名年龄在2至13岁（平均9.5±1.3岁）的儿童，这些儿童因个人症状（14例）或作为MH易感家族成员（12例）接受检测。一半儿童的检测结果呈阳性（MHS和MHE），这与在成人中发现的情况相同。此外，氟烷和咖啡因阈值浓度以及32 nmol咖啡因诱导的挛缩与年龄的比较未显示出显著差异。这些结果支持了从2岁起在良好条件下并以良好可靠性对儿童进行恶性高热易感性诊断测试的可能性。
