Britt B A, Scott E A
Anesth Analg. 1986 Feb;65(2):171-5.
A platelet-halothane nucleotide or bioassay test has been suggested as an accurate means for diagnosis of malignant hyperthermia (MH). For the last three years we performed this test in all patients at risk for MH and in all normal control patients undergoing skeletal muscle biopsy in our diagnostic unit. The reliability of the platelet-halothane nucleotide test has been assessed on the basis of the presence or absence of a previous MH reaction and degree of relationship of relatives to those who have had reactions, and on the basis of caffeine-halothane contracture test values (positive or negative for MH). We have found no significant difference in platelet-halothane nucleotide test values in malignant hyperthermia susceptible (MHS) patients or relatives of MHS patients and normal controls, and no relationship between the nucleotide test and caffeine-halothane contracture test results. We conclude that the platelet-halothane nucleotide test is not of assistance in the diagnosis of or in the screening for MH.
血小板-氟烷核苷酸试验或生物测定试验已被提议作为诊断恶性高热（MH）的一种准确方法。在过去三年中，我们对所有有MH风险的患者以及在我们诊断科室接受骨骼肌活检的所有正常对照患者都进行了这项试验。血小板-氟烷核苷酸试验的可靠性已根据既往是否有MH反应以及亲属与有反应者的亲缘关系程度进行评估，并根据咖啡因-氟烷挛缩试验值（MH阳性或阴性）进行评估。我们发现，恶性高热易感（MHS）患者或MHS患者的亲属与正常对照者在血小板-氟烷核苷酸试验值上没有显著差异，并且核苷酸试验与咖啡因-氟烷挛缩试验结果之间没有关联。我们得出结论，血小板-氟烷核苷酸试验对MH的诊断或筛查没有帮助。
