Pinkoviezky I, Gov N S
Department of Chemical Physics, Weizmann Institute of Science, P.O. Box 26, Rehovot, Israel 76100.
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Aug;88(2):022714. doi: 10.1103/PhysRevE.88.022714. Epub 2013 Aug 20.
Molecular motors are involved in key transport processes in the cell. Many of these motors can switch from an active to a nonactive state, either spontaneously or depending on their interaction with other molecules. When active, the motors move processively along the filaments, while when inactive they are stationary. We treat here the simple case of spontaneously switching motors, between the active and inactive states, along an open linear track. We use our recent analogy with vehicular traffic, where we go beyond the mean-field description. We map the phase diagram of this system, and find that it clearly breaks the symmetry between the different phases, as compared to the standard total asymmetric exclusion process. We make several predictions that may be testable using molecular motors in vitro and in living cells.
分子马达参与细胞中的关键运输过程。这些马达中的许多能够自发地或根据它们与其他分子的相互作用从活跃状态转变为非活跃状态。当处于活跃状态时，马达沿着细丝进行连续移动，而当处于非活跃状态时它们则静止不动。我们在此处理沿着开放线性轨道在活跃和非活跃状态之间自发切换的马达的简单情况。我们利用我们最近与车辆交通的类比，在此类比中我们超越了平均场描述。我们绘制了该系统的相图，并且发现与标准的完全非对称排斥过程相比，它明显打破了不同相之间的对称性。我们做出了几个可以在体外和活细胞中使用分子马达进行测试的预测。
