Bröjer J, Lindåse S, Hedenskog J, Alvarsson K, Nostell K
Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
J Vet Intern Med. 2013 Nov-Dec;27(6):1543-50. doi: 10.1111/jvim.12172. Epub 2013 Aug 28.
The increasing number of horses diagnosed with insulin resistance (IR) and the suggested link between IR and laminitis has highlighted the need to accurately diagnose IR in clinical practice.
HYPOTHESIS/OBJECTIVES: The aim of the study was to evaluate the repeatability of the combined glucose-insulin tolerance test (CGIT) as well as to determine the effect of 2 different breeds and the effect of a stressor on the test results.
Clinically normal horses, 9 Standardbred horses and 9 Icelandic horses.
Prospective clinical nonrandomized trial. The CGIT was performed on all horses on 2 occasions 3 weeks apart. An additional CGIT was performed on four of the Standardbred and four of the Icelandic horses after transportation to a new environment (stressor) the day before testing.
Calculated parameters for the glucose curve of the CGIT had low repeatability, whereas the parameters for the insulin curve had high repeatability. There was an effect of breed (Standarbred versus Icelandic horse) as well as stress on the glucose dynamics, but not on the insulin dynamics of the CGIT.
Repeatability of the glucose dynamics of the CGIT is low. In addition, there appears to be breed differences in the glucose dynamics. It is therefore suggested that diagnosis of IR should not be made solely based on results from the glucose curve of the CGIT.
被诊断出患有胰岛素抵抗（IR）的马匹数量不断增加，以及IR与蹄叶炎之间的潜在联系，凸显了在临床实践中准确诊断IR的必要性。
假设/目标：本研究的目的是评估联合葡萄糖-胰岛素耐量试验（CGIT）的可重复性，并确定两种不同品种以及应激源对试验结果的影响。
临床健康的马匹，9匹标准赛马和9匹冰岛马。
前瞻性临床非随机试验。对所有马匹进行两次CGIT，间隔3周。在测试前一天，将4匹标准赛马和4匹冰岛马运输到新环境（应激源）后，对它们进行额外的CGIT。
CGIT葡萄糖曲线的计算参数重复性较低，而胰岛素曲线的参数重复性较高。品种（标准赛马与冰岛马）以及应激对CGIT的葡萄糖动态有影响，但对胰岛素动态没有影响。
CGIT葡萄糖动态的可重复性较低。此外，葡萄糖动态似乎存在品种差异。因此，建议不应仅根据CGIT葡萄糖曲线的结果来诊断IR。
