Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan 610041, China.
Chin Med J (Engl). 2013;126(17):3360-3.
Numerous studies have evaluated the association between interleukin-18 (IL-18) promoter gene -607C/ A (rs1946518) polymorphism and tuberculosis (TB) risk. However, the results remain apparently conflicting. The aim of this study was to investigate whether IL-18-607C/A polymorphism is associated with susceptibility to TB.
Publications addressing the association between the IL-18-607C/A polymorphism and TB risk were selected from the Pubmed, Cochrane Library, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.0.25 and STATA 11.0 software.
Eight case-control studies with a total of 1166 TB patients and 1734 controls were retrieved. Meta-analysis results showed significant association between IL-18-607C/A polymorphism and TB risk in all comparisons of the A allele versus C allele (OR=1.17, 95% CI 1.05-1.30, P=0.004), AA versus CC (OR=1.43, 95% CI 1.14-1.81, P=0.002), CA+AA versus CC (OR=1.20, 95% CI 1.01-1.42, P=0.04) and AA versus CA+CC (OR=1.30, 95% CI 1.07-1.58, P=0.007). In subgroup analysis by nationality, a significant association between IL-18-607C/A polymorphism and TB risk in the comparisons of A versus C, CA+AA versus CC and AA versus CA+CC (OR=1.22, 95% CI 1.07-1.38, P=0.002; OR=1.31, 95% CI 1.06-1.61, P=0.01; OR=1.32, 95% CI 1.07-1.63, P=0.01, respectively) were found in Chinese population but not in Indian and Iranian populations.
This study suggests that the -607C/A polymorphism of IL-18 gene would be a risk factor for TB, especially in Chinese population. To further evaluate gene-to-gene and gene-to-environment interactions on -607C/A polymorphism and tuberculosis risk, more studies with thousands of patients are required.
许多研究评估了白细胞介素-18（IL-18）启动子基因-607C/A（rs1946518）多态性与结核病（TB）风险之间的关联。然而，结果仍然存在明显的冲突。本研究旨在探讨白细胞介素-18-607C/A 多态性是否与 TB 易感性相关。
从 Pubmed、Cochrane 图书馆、Embase、CNKI 和万方数据库中选择了与白细胞介素-18-607C/A 多态性与 TB 风险相关的研究。由两名独立的评审员从研究中提取数据。使用 RevMan 5.0.25 和 STATA 11.0 软件进行统计分析。
共检索到 8 项病例对照研究，共纳入 1166 例 TB 患者和 1734 例对照。Meta 分析结果显示，A 等位基因与 C 等位基因（OR=1.17，95%CI 1.05-1.30，P=0.004）、AA 与 CC（OR=1.43，95%CI 1.14-1.81，P=0.002）、CA+AA 与 CC（OR=1.20，95%CI 1.01-1.42，P=0.04）和 AA 与 CA+CC（OR=1.30，95%CI 1.07-1.58，P=0.007）相比，IL-18-607C/A 多态性与 TB 风险之间存在显著关联。按国籍进行亚组分析，在中国人群中，IL-18-607C/A 多态性与 TB 风险的 A 与 C、CA+AA 与 CC 和 AA 与 CA+CC 比较中存在显著相关性（OR=1.22，95%CI 1.07-1.38，P=0.002；OR=1.31，95%CI 1.06-1.61，P=0.01；OR=1.32，95%CI 1.07-1.63，P=0.01，分别），但在印度和伊朗人群中没有发现。
本研究表明，白细胞介素-18 基因的-607C/A 多态性可能是 TB 的一个危险因素，尤其是在中国人群中。为了进一步评估-607C/A 多态性与结核病风险的基因-基因和基因-环境相互作用，需要更多的包含数千名患者的研究。
