Couraud S, Labonne S, Missy P, Morin F, Tran Q, Deroy A, Milleron B, Blanché H, Zalcman G, Souquet P-J
Service de pneumologie et oncologie thoracique, hospices civils de Lyon, centre hospitalier Lyon Sud, 165 chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France; Faculté de médecine Lyon Sud - Charles Mérieux, université Lyon 1, 69600 Oullins, France; Intergroupe francophone de cancérologie thoracique, Paris, France.
Rev Mal Respir. 2013 Sep;30(7):576-83. doi: 10.1016/j.rmr.2013.03.006. Epub 2013 May 18.
Around 5 to 25% of lung cancer worldwide occurs in lifelong non-smokers (less than 100 cigarettes in lifetime). Lung cancer in never smokers (LCINS) shows many clinical, epidemiological and molecular differences compared to those related to tobacco. It is therefore often considered as a separate entity. LCINS is also a good model for the study of lung cancer risk factors and tumoral mutation profiles (usually more common and specific). However, most data has come from retrospective studies and/or from Asian populations, although this disease shows high geographic lability. The BioCAST/IFCT-1002 is a national, multicentric, prospective study promoted by the French intergroup IFCT. The first objective is to describe the clinical and molecular epidemiology of LCINS in a French population. Detailed data (including exposure to many risk factors) are collected directly from the patient through a standardized questionnaire completed during a telephone interview. All patients also undergo blood sampling for the analysis of genomic polymorphisms and the characterization of epigenetic anomalies. BioCAST hopes to provide concrete answers for clinicians and patients about this entity.
全球约5%至25%的肺癌发生在终生不吸烟者（终生吸烟少于100支）中。与吸烟相关的肺癌相比，从不吸烟者肺癌（LCINS）在临床、流行病学和分子方面存在许多差异。因此，它常被视为一个独立的实体。LCINS也是研究肺癌危险因素和肿瘤突变谱（通常更常见且更具特异性）的良好模型。然而，尽管这种疾病具有高度的地域变异性，但大多数数据来自回顾性研究和/或亚洲人群。BioCAST/IFCT - 1002是一项由法国跨组织IFCT推动的全国性、多中心前瞻性研究。首要目标是描述法国人群中LCINS的临床和分子流行病学情况。通过电话访谈期间完成的标准化问卷直接从患者处收集详细数据（包括接触多种危险因素的情况）。所有患者还需进行血液采样，以分析基因组多态性并表征表观遗传异常。BioCAST希望为临床医生和患者提供有关该实体的具体答案。
