Fischer Wolfgang B, Li Li-Hua, Mahato Dhani Ram, Wang Yi-Ting, Chen Chin-Pei
Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
Biochim Biophys Acta. 2014 Apr;1838(4):1113-21. doi: 10.1016/j.bbamem.2013.08.017. Epub 2013 Sep 12.
Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.
病毒通道形成蛋白以其能够使宿主细胞及其亚细胞区室的脂质膜对离子和小分子化合物具有通透性而闻名。越来越多的证据表明，这类蛋白中的一些代表也与宿主蛋白强烈相互作用，而且这种相互作用的效率似乎很高。通过生物信息学方法已经提出了病毒通道蛋白与宿主因子的相互作用，并且也已通过实验得到证实。本文概述了HIV-1的Vpu、HPV-16的E5和HCV的p7与宿主蛋白的相互作用。本文是名为《病毒膜蛋白——细胞网络通道》特刊的一部分。
