Talas Zeliha Selamoglu, Gogebakan Ayse, Orun Ibrahim
Department of Biology, Faculty of Arts and Sciences, Nigde University, Nigde, Turkey.
Pak J Pharm Sci. 2013 Sep;26(5):915-9.
This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased (P<0.05). The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased (P<0.05). L-NAME caused increase (P<0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (P<0.05), platelets and lymphocyte increased (P<0.05) in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide.
本研究显示了蜂胶对Nω-硝基-L-精氨酸甲酯（L-NAME）诱导的慢性一氧化氮合酶抑制大鼠生化和血液学参数的影响。给大鼠连续15天给予L-NAME，并在最后5天与L-NAME一起给予蜂胶。与对照组相比，L-NAME组的天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶和γ-谷氨酰转移酶水平升高（P<0.05）。与L-NAME组相比，L-NAME+蜂胶组这些参数的水平降低（P<0.05）。L-NAME导致葡萄糖、白蛋白、球蛋白、肌酐、尿素、甘油三酯和胆固醇水平升高（P<0.05）。与L-NAME组相比，L-NAME+蜂胶组的红细胞数量、总白细胞、血红蛋白、血细胞比容、中性粒细胞和单核细胞减少（P<0.05），血小板和淋巴细胞增加（P<0.05）。该研究得出结论，通过添加蜂胶可调节L-NAME给药大鼠的体内稳态，这会导致血管一氧化氮生成增加。
