Uehling D T, Hopkins W J, Balish E
Department of Surgery (Urology), University of Wisconsin, Madison.
J Urol. 1990 Jan;143(1):143-5. doi: 10.1016/s0022-5347(17)39898-1.
In an attempt to further increase the protective effect of vaginal immunization against urinary tract infections in Cynomolgus monkeys, the immunogen of killed E. coli was given more times, in larger amounts, and with the adjuvant MDP. Instead of increasing the protective effect, no protective effect on induced cystitis was observed. In addition, rises in urinary and serum immunoglobulins previously observed after vaginal immunization and induced cystitis were lessened. These observations appear to correspond with the classical concepts of immunologic unresponsiveness.
为了进一步增强食蟹猴阴道免疫对尿路感染的保护作用，采用更多次数、更大剂量并联合佐剂MDP给予灭活大肠杆菌免疫原。然而，不但没有增强保护作用，反而未观察到对诱导性膀胱炎的保护效果。此外，先前在阴道免疫和诱导性膀胱炎后观察到的尿液和血清免疫球蛋白升高现象也有所减轻。这些观察结果似乎与免疫无反应性的经典概念相符。
