Uehling D T, James L J, Hopkins W J, Balish E
Department of Surgery (Urology), University of Wisconsin Medical School, Madison.
J Urol. 1991 Jul;146(1):223-6. doi: 10.1016/s0022-5347(17)37756-x.
Systemic and local immune responses are thought to play an important role in susceptibility to urinary tract infection. In an attempt to boost local immunity, a vaccine was administered parenterally or vaginally to two mouse strains. Both routes of immunization increased the number of splenic antibody-forming cells against the bacterial strains in the vaccine. Following vaginal or parenteral immunization and subsequent induction of cystitis with live E. coli, immunized animals had fewer viable bladder E. coli than non-immunized animals.
全身和局部免疫反应被认为在尿路感染易感性中起重要作用。为了增强局部免疫力，将一种疫苗通过非肠道途径或阴道途径接种给两种小鼠品系。两种免疫途径均增加了针对疫苗中细菌菌株的脾抗体形成细胞数量。在阴道或非肠道免疫以及随后用活大肠杆菌诱导膀胱炎后，免疫动物膀胱中存活的大肠杆菌数量比未免疫动物少。
