Sarker Md Mosharrof Hossain, Zhou Meng Chu, Rameshwar Pranela, Hanover John A
Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA,
Cell Biochem Biophys. 2014 Apr;68(3):577-82. doi: 10.1007/s12013-013-9743-0.
The divergence of protein (Hedgehog) in different organisms remains an unresolved issue to comprehend how the pathway in Hh signaling evolves. Insights into this question can help one identify the key molecules in Hh signaling. This work proposes a protein-associated factor in cells. The development of a non-reductionist theory of cellular functions in medicine is not sufficient. It is necessary to find the parameters with regards to molecules/genes that can elicit functions. This work shows that molecular interactions of gene products can be accomplished by biophysics logic. Defining the protein-associated factors in molecular activities and identifying its roles in molecular transduction are important. A misregulation in molecular switch can account for complex biomolecular consequences. This work shows the potential of the factor on homo-sapiens and unlocks its implications to gene multi-tasking functionality. The associated factor notion should facilitate the medical development in cancer therapeutics.
蛋白质(刺猬蛋白)在不同生物体中的差异仍然是一个尚未解决的问题,难以理解刺猬信号通路是如何进化的。深入了解这个问题有助于识别刺猬信号通路中的关键分子。这项工作提出了一种细胞内与蛋白质相关的因子。医学中关于细胞功能的非还原论理论的发展还不够充分。有必要找到能够引发功能的分子/基因相关参数。这项工作表明,基因产物的分子相互作用可以通过生物物理逻辑来实现。定义分子活动中与蛋白质相关的因子并确定其在分子转导中的作用很重要。分子开关的失调可能导致复杂的生物分子后果。这项工作展示了该因子在人类中的潜力,并揭示了其对基因多任务功能的影响。相关因子的概念应该会促进癌症治疗的医学发展。