Jiang Jin, Hui Chi-Chung
Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010.
The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.
分泌蛋白的刺猬（Hh）家族在胚胎发育和成年组织稳态过程中调控着各种各样的过程。在此，我们综述了目前对Hh形态发生素梯度形成和信号转导的分子和细胞基础，以及Hh信号在发育和肿瘤发生中的多方面作用的理解。我们讨论了Hh信号通路在进化过程中是如何分化的，以及它如何与其他信号通路整合以控制细胞生长和模式形成。
