发育与癌症中的刺猬信号通路
Hedgehog signaling in development and cancer.
作者信息
Jiang Jin, Hui Chi-Chung
机构信息
Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
出版信息
Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010.
Abstract
The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.
摘要
分泌蛋白的刺猬（Hh）家族在胚胎发育和成年组织稳态过程中调控着各种各样的过程。在此，我们综述了目前对Hh形态发生素梯度形成和信号转导的分子和细胞基础，以及Hh信号在发育和肿瘤发生中的多方面作用的理解。我们讨论了Hh信号通路在进化过程中是如何分化的，以及它如何与其他信号通路整合以控制细胞生长和模式形成。
相似文献
1
Hedgehog signaling in development and cancer.
Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010.
2
Intricacies of hedgehog signaling pathways: a perspective in tumorigenesis.
Exp Cell Res. 2012 Oct 1;318(16):1959-72. doi: 10.1016/j.yexcr.2012.05.015. Epub 2012 May 31.
3
Hedgehog signal transduction: signal integration and cross talk in development and cancer.
Cell Cycle. 2006 Aug;5(15):1612-5. doi: 10.4161/cc.5.15.3130. Epub 2006 Aug 1.
4
Logical modelling of the role of the Hh pathway in the patterning of the Drosophila wing disc.
Bioinformatics. 2008 Aug 15;24(16):i234-40. doi: 10.1093/bioinformatics/btn266.
5
Decoding the Hedgehog signal in animal development.
Cell Mol Life Sci. 2006 Jun;63(11):1249-65. doi: 10.1007/s00018-005-5519-z.
6
Decoding Ci: from partial degradation to inhibition.
Dev Growth Differ. 2015 Feb;57(2):98-108. doi: 10.1111/dgd.12187. Epub 2014 Dec 14.
7
Proliferative and cell fate effects of Hedgehog signaling in the vertebrate retina.
Brain Res. 2008 Feb 4;1192:61-75. doi: 10.1016/j.brainres.2007.06.018. Epub 2007 Jun 16.
8
The Hedgehog signalling pathway in bone formation.
Int J Oral Sci. 2015 Jun 26;7(2):73-9. doi: 10.1038/ijos.2015.14.
9
Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.
Exp Cell Res. 2009 Sep 10;315(15):2648-57. doi: 10.1016/j.yexcr.2009.06.018. Epub 2009 Jun 24.
10
Hedgehog signaling pathway as a therapeutic target in various types of cancer.
Cancer Sci. 2011 Oct;102(10):1756-60. doi: 10.1111/j.1349-7006.2011.02010.x. Epub 2011 Jul 26.
引用本文的文献
1
Cell-Based Assays to Study SUMOylation in Drosophila.
Methods Mol Biol. 2025;2957:119-125. doi: 10.1007/978-1-0716-4710-3_8.
2
SMARCB1-related schwannomatosis and other SMARCB1-associated phenotypes: clinical spectrum and molecular pathogenesis.
Fam Cancer. 2025 Aug 12;24(3):64. doi: 10.1007/s10689-025-00486-4.
3
Is Axis Definition a Fluctuation-Based Process Picking Up External Cues?
J Dev Biol. 2025 Jul 17;13(3):24. doi: 10.3390/jdb13030024.
4
A male-essential miRNA is key for avian sex chromosome dosage compensation.
Nature. 2025 Jul 16. doi: 10.1038/s41586-025-09256-9.
5
Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila.
EMBO J. 2025 Jun 23. doi: 10.1038/s44318-025-00489-y.
6
Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis.
Pharmaceutics. 2025 Apr 24;17(5):559. doi: 10.3390/pharmaceutics17050559.
7
VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer.
Int J Biol Sci. 2025 Apr 28;21(7):3144-3163. doi: 10.7150/ijbs.107279. eCollection 2025.
8
Extracellular vesicles play a central role in linking podocyte injury to mesangial activation in glomerular disease.
Theranostics. 2025 Apr 9;15(11):5121-5137. doi: 10.7150/thno.110034. eCollection 2025.
9
Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal.
J Cell Sci. 2025 Oct 15;138(20). doi: 10.1242/jcs.263695. Epub 2025 May 19.
10
Regulation of autophagy by protein lipidation.
Adv Biotechnol (Singap). 2024 Sep 20;2(4):33. doi: 10.1007/s44307-024-00040-w.
本文引用的文献
1
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
Nature. 2008 Dec 18;456(7224):967-70. doi: 10.1038/nature07459.
2
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb.
Genes Dev. 2008 Oct 1;22(19):2651-63. doi: 10.1101/gad.1693008.
3
Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.
Sci Signal. 2008 Sep 30;1(39):ra7. doi: 10.1126/scisignal.1162925.
4
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.
Cancer Cell. 2008 Sep 9;14(3):238-49. doi: 10.1016/j.ccr.2008.08.003.
5
A paracrine requirement for hedgehog signalling in cancer.
Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.
6
Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.
Curr Biol. 2008 Aug 26;18(16):1215-20. doi: 10.1016/j.cub.2008.07.026. Epub 2008 Aug 7.
7
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
Cancer Cell. 2008 Aug 12;14(2):135-45. doi: 10.1016/j.ccr.2008.07.003.
8
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer Cell. 2008 Aug 12;14(2):123-34. doi: 10.1016/j.ccr.2008.07.005.
9
A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation.
Mol Cell Biol. 2008 Sep;28(18):5555-68. doi: 10.1128/MCB.00524-08. Epub 2008 Jul 14.
10
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.
Dev Biol. 2008 Sep 1;321(1):188-96. doi: 10.1016/j.ydbio.2008.06.014. Epub 2008 Jun 18.
Zotero 插件