发育与癌症中的刺猬信号通路
Hedgehog signaling in development and cancer.
作者信息
Jiang Jin, Hui Chi-Chung
机构信息
Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
出版信息
Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010.
Abstract
The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.
摘要
分泌蛋白的刺猬（Hh）家族在胚胎发育和成年组织稳态过程中调控着各种各样的过程。在此，我们综述了目前对Hh形态发生素梯度形成和信号转导的分子和细胞基础，以及Hh信号在发育和肿瘤发生中的多方面作用的理解。我们讨论了Hh信号通路在进化过程中是如何分化的，以及它如何与其他信号通路整合以控制细胞生长和模式形成。
相似文献
1
Hedgehog signaling in development and cancer.发育与癌症中的刺猬信号通路
Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010.
2
Intricacies of hedgehog signaling pathways: a perspective in tumorigenesis.刺猬信号通路的复杂性：肿瘤发生学视角
Exp Cell Res. 2012 Oct 1;318(16):1959-72. doi: 10.1016/j.yexcr.2012.05.015. Epub 2012 May 31.
3
Hedgehog signal transduction: signal integration and cross talk in development and cancer.刺猬信号转导：发育与癌症中的信号整合及相互作用
Cell Cycle. 2006 Aug;5(15):1612-5. doi: 10.4161/cc.5.15.3130. Epub 2006 Aug 1.
4
Logical modelling of the role of the Hh pathway in the patterning of the Drosophila wing disc.Hh信号通路在果蝇翅盘模式形成中作用的逻辑建模。
Bioinformatics. 2008 Aug 15;24(16):i234-40. doi: 10.1093/bioinformatics/btn266.
5
Decoding the Hedgehog signal in animal development.解析动物发育过程中的刺猬信号通路
Cell Mol Life Sci. 2006 Jun;63(11):1249-65. doi: 10.1007/s00018-005-5519-z.
6
Decoding Ci: from partial degradation to inhibition.破解Ci：从部分降解到抑制
Dev Growth Differ. 2015 Feb;57(2):98-108. doi: 10.1111/dgd.12187. Epub 2014 Dec 14.
7
Proliferative and cell fate effects of Hedgehog signaling in the vertebrate retina.脊椎动物视网膜中刺猬信号通路的增殖及细胞命运效应
Brain Res. 2008 Feb 4;1192:61-75. doi: 10.1016/j.brainres.2007.06.018. Epub 2007 Jun 16.
8
The Hedgehog signalling pathway in bone formation.骨形成中的刺猬信号通路。
Int J Oral Sci. 2015 Jun 26;7(2):73-9. doi: 10.1038/ijos.2015.14.
9
Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.刺猬信号激活协调胎儿肝脏祖细胞的增殖和分化。
Exp Cell Res. 2009 Sep 10;315(15):2648-57. doi: 10.1016/j.yexcr.2009.06.018. Epub 2009 Jun 24.
10
Hedgehog signaling pathway as a therapeutic target in various types of cancer.刺猬信号通路作为各种类型癌症的治疗靶点。
Cancer Sci. 2011 Oct;102(10):1756-60. doi: 10.1111/j.1349-7006.2011.02010.x. Epub 2011 Jul 26.
引用本文的文献
1
Cell-Based Assays to Study SUMOylation in Drosophila.基于细胞的分析方法研究果蝇中的SUMO化修饰
Methods Mol Biol. 2025;2957:119-125. doi: 10.1007/978-1-0716-4710-3_8.
2
SMARCB1-related schwannomatosis and other SMARCB1-associated phenotypes: clinical spectrum and molecular pathogenesis.与SMARCB1相关的神经鞘瘤病及其他与SMARCB1相关的表型：临床谱与分子发病机制
Fam Cancer. 2025 Aug 12;24(3):64. doi: 10.1007/s10689-025-00486-4.
3
Is Axis Definition a Fluctuation-Based Process Picking Up External Cues?轴突定义是一个基于波动并接收外部线索的过程吗？
J Dev Biol. 2025 Jul 17;13(3):24. doi: 10.3390/jdb13030024.
4
A male-essential miRNA is key for avian sex chromosome dosage compensation.一种雄性必需的微小RNA对鸟类性染色体剂量补偿至关重要。
Nature. 2025 Jul 16. doi: 10.1038/s41586-025-09256-9.
5
Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila.脂肪组织分泌的Spz5通过果蝇中Toll-6介导的Hh信号通路激活促进远端肿瘤进展。
EMBO J. 2025 Jun 23. doi: 10.1038/s44318-025-00489-y.
6
Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis.突破抗性：光动力疗法在癌症干细胞驱动的肿瘤发生中的应用
Pharmaceutics. 2025 Apr 24;17(5):559. doi: 10.3390/pharmaceutics17050559.
7
VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer.VRK1/BANF1/GLI1轴调控结直肠癌的肿瘤发生与进展。
Int J Biol Sci. 2025 Apr 28;21(7):3144-3163. doi: 10.7150/ijbs.107279. eCollection 2025.
8
Extracellular vesicles play a central role in linking podocyte injury to mesangial activation in glomerular disease.细胞外囊泡在肾小球疾病中将足细胞损伤与系膜激活联系起来的过程中起着核心作用。
Theranostics. 2025 Apr 9;15(11):5121-5137. doi: 10.7150/thno.110034. eCollection 2025.
9
Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal.磷酸化诱导的SUMO化促进Ulk4在纤毛顶端凝聚以转导Hedgehog信号。
J Cell Sci. 2025 Oct 15;138(20). doi: 10.1242/jcs.263695. Epub 2025 May 19.
10
Regulation of autophagy by protein lipidation.蛋白质脂化对自噬的调控。
Adv Biotechnol (Singap). 2024 Sep 20;2(4):33. doi: 10.1007/s44307-024-00040-w.
本文引用的文献
1
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.G蛋白α亚基（Galphai）在刺猬信号通路中位于Smoothened蛋白的下游，发挥直接作用。
Nature. 2008 Dec 18;456(7224):967-70. doi: 10.1038/nature07459.
2
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb.对刺猬索尼克介导的哺乳动物肢体模式形成背后的顺式调控电路进行全基因组规模分析。
Genes Dev. 2008 Oct 1;22(19):2651-63. doi: 10.1101/gad.1693008.
3
Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.激酶组siRNA筛选鉴定出纤毛发生和刺猬信号转导的调节因子。
Sci Signal. 2008 Sep 30;1(39):ra7. doi: 10.1126/scisignal.1162925.
4
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.Bcr-Abl阳性白血病干细胞的扩增依赖于Hedgehog信号通路的激活。
Cancer Cell. 2008 Sep 9;14(3):238-49. doi: 10.1016/j.ccr.2008.08.003.
5
A paracrine requirement for hedgehog signalling in cancer.癌症中刺猬信号通路的旁分泌需求
Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.
6
Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.肋2在刺猬信号转导通路中作为一种类驱动蛋白发挥作用。
Curr Biol. 2008 Aug 26;18(16):1215-20. doi: 10.1016/j.cub.2008.07.026. Epub 2008 Aug 7.
7
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.髓母细胞瘤可由谱系受限的祖细胞或干细胞中patched基因的缺失引发。
Cancer Cell. 2008 Aug 12;14(2):135-45. doi: 10.1016/j.ccr.2008.07.003.
8
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.获得颗粒神经元前体身份是祖细胞形成 Sonic Hedgehog（Shh）诱导的髓母细胞瘤能力的关键决定因素。
Cancer Cell. 2008 Aug 12;14(2):123-34. doi: 10.1016/j.ccr.2008.07.005.
9
A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation.翅脉中断蛋白中的一种独特保护信号可防止其被蛋白酶体完全降解。
Mol Cell Biol. 2008 Sep;28(18):5555-68. doi: 10.1128/MCB.00524-08. Epub 2008 Jul 14.
10
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.Smoothened与Galphai蛋白的解偶联对Gli3蛋白加工和刺猬因子调节的鸡神经管模式形成影响很小。
Dev Biol. 2008 Sep 1;321(1):188-96. doi: 10.1016/j.ydbio.2008.06.014. Epub 2008 Jun 18.
Zotero 插件