Department of Biomedical Sciences, College of Veterinary Medicine, T7 022A Veterinary Research Tower (Box 17), Cornell University, Ithaca, NY, 14853, USA,
Obes Surg. 2013 Dec;23(12):2042-9. doi: 10.1007/s11695-013-1076-y.
Increasing numbers of people are undergoing bariatric surgery, of which approximately half are women in their childbearing years. However, information on the long-term effects of maternal bariatric surgery in their children is lacking. Furthermore, since bariatric surgery is performed to reduce body weight, clinical studies have not been able to differentiate between benefits to the child due to maternal body weight loss versus other maternal postoperative metabolic changes. Therefore, we used the University of California, Davis, type 2 diabetes mellitus (UCD-T2DM) rat model to test the hypothesis that maternal ileal interposition (IT) surgery would confer beneficial metabolic effects in offspring, independent of effects on maternal body weight.
IT surgery was performed on 2-month-old prediabetic female UCD-T2DM rats. Females were bred 3 weeks after surgery, and male pups were studied longitudinally.
Maternal IT surgery resulted in decreased body weight in offspring compared with sham offspring (P < 0.05). IT offspring exhibited improvements of glucose-stimulated insulin secretion and nutrient-stimulated glucagon-like peptide-2 (GLP-2) secretion (P < 0.05). Fasting plasma unconjugated bile acid concentrations were 4-fold lower in IT offspring compared with sham offspring at two months of age (P < 0.001).
Overall, maternal IT surgery confers modest improvements of body weight and improves insulin secretion and nutrient-stimulated GLP-2 secretion in offspring in the UCD-T2DM rat model of type 2 diabetes, indicating that this is a useful model for investigating the weight-independent metabolic effects of maternal bariatric surgery.
越来越多的人接受减重手术，其中约有一半是处于生育年龄的女性。然而，关于母亲接受减重手术后对其子女的长期影响的信息却很少。此外，由于减重手术是为了减轻体重而进行的，临床研究无法区分母亲体重减轻对孩子的益处与母亲术后其他代谢变化的益处。因此，我们使用加利福尼亚大学戴维斯分校 2 型糖尿病（UCD-T2DM）大鼠模型来检验以下假设，即母亲回肠旁路（IT）手术将对后代产生有益的代谢影响，而与对母亲体重的影响无关。
对 2 个月大的糖尿病前期雌性 UCD-T2DM 大鼠进行 IT 手术。手术后 3 周进行配种，对雄性幼崽进行纵向研究。
与假手术后代相比，母亲的 IT 手术导致后代体重减轻（P<0.05）。IT 后代表现出葡萄糖刺激的胰岛素分泌和营养刺激的胰高血糖素样肽-2（GLP-2）分泌改善（P<0.05）。与假手术后代相比，2 个月大时 IT 后代的空腹血浆未结合胆汁酸浓度低 4 倍（P<0.001）。
总体而言，母亲的 IT 手术使 2 型糖尿病 UCD-T2DM 大鼠模型中的后代体重适度减轻，并改善了胰岛素分泌和营养刺激的 GLP-2 分泌，表明这是研究母亲减重手术的体重独立代谢影响的有用模型。
