Laboratory of Surgical Research, Marie Lannelongue Hospital, University of Paris Sud, Le Plessis Robinson, France.
Semin Respir Crit Care Med. 2013 Oct;34(5):689-99. doi: 10.1055/s-0033-1355444. Epub 2013 Sep 13.
The right ventricle (RV) faces major changes in loading conditions associated with cardiovascular and pulmonary vascular disorders. Despite major pharmacological advances since the last decade, pulmonary arterial hypertension remains a deadly disease mainly secondary to the development of right ventricular failure (RVF). Several experimental models of RVF have been developed over the past three decades providing a particular insight in RV pathophysiology. Mechanisms involved in the transition from RV adaptive hypertrophy to maladaptive remodeling and failure in conditions of chronic RV pressure or volume overload are of a great interest but not yet completely understood. Further investigations are needed to find new therapeutic approaches for RVF. Current animal models and emerging concepts of translational RV research will be detailed in this review.
右心室（RV）面临与心血管和肺血管疾病相关的负荷条件的重大变化。尽管过去十年有了重大的药物学进展，但肺动脉高压仍然是一种致命疾病，主要是由于右心衰竭（RVF）的发展。在过去的三十年中，已经开发了几种 RVF 的实验模型，为 RV 病理生理学提供了独特的见解。在慢性 RV 压力或容量超负荷的情况下，从 RV 适应性肥大到适应性重构和衰竭的转变所涉及的机制非常重要，但尚未完全理解。需要进一步研究以寻找 RVF 的新治疗方法。本综述将详细介绍当前的动物模型和转化 RV 研究的新观点。
