旨在更好地理解和管理癌症相关性疲劳。
Aiming for a better understanding and management of cancer-related fatigue.
机构信息
Department of Medical Oncology and.
出版信息
Oncologist. 2013;18(10):1135-43. doi: 10.1634/theoncologist.2013-0076. Epub 2013 Sep 13.
Abstract
Cancer-related fatigue (CRF) is a serious symptom of patients with cancer and deteriorates their daily quality of life. Whereas fatigue is a common problem in the general population, with a prevalence of about 30%, up to 99% of patients with cancer have fatigue of more intense severity. CRF is directly related to the biology of cancer, but it can also be caused by anticancer treatment. We reviewed current evidence about the potential pathophysiological mechanisms causing CRF. Clinical methods to determine the presence and severity of CRF and potential treatment options to reduce CRF will be discussed. After reading this review, the reader will have knowledge of the current understanding of CRF and will be able to give evidence-based advice to patients with CRF.
摘要
癌因性疲乏（CRF）是癌症患者的一种严重症状，会降低他们的日常生活质量。虽然疲乏是普通人群中的常见问题，其患病率约为 30%，但多达 99%的癌症患者存在更为严重的疲乏。CRF 与癌症的生物学直接相关，但也可能由抗癌治疗引起。我们综述了目前关于导致 CRF 的潜在病理生理学机制的证据。本文将讨论确定 CRF 存在和严重程度的临床方法以及减轻 CRF 的潜在治疗选择。阅读本综述后，读者将了解目前对 CRF 的认识，并能够为 CRF 患者提供基于证据的建议。
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J Clin Oncol. 2013 Sep 1;31(25):3076-82. doi: 10.1200/JCO.2012.44.4661. Epub 2013 Jul 29.
2
Methylphenidate and/or a nursing telephone intervention for fatigue in patients with advanced cancer: a randomized, placebo-controlled, phase II trial.哌醋甲酯和/或护理电话干预对晚期癌症患者疲劳的影响：一项随机、安慰剂对照、Ⅱ期试验。
J Clin Oncol. 2013 Jul 1;31(19):2421-7. doi: 10.1200/JCO.2012.45.3696. Epub 2013 May 20.
3
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