评价来自不同种族人群全基因组关联研究的与前列腺癌风险相关的 SNP 在华人群体中的应用。
Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men.
机构信息
Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR, China.
出版信息
Prostate. 2013 Nov;73(15):1623-35. doi: 10.1002/pros.22629. Epub 2013 Sep 9.
BACKGROUND
Several genome-wide association studies (GWAS) of prostate cancer (PCa) have identified many single nucleotide polymorphisms (SNPs) that are significantly associated with PCa risk in various racial groups. The objective of this study is to evaluate which of these SNPs are associated with PCa risk in Chinese men and estimate their strength of association.
METHODS
All SNPs that were reported to be associated with PCa risk in GWAS from populations of European, African American, Japanese, and Chinese descent were evaluated in 1,922 PCa cases and 2,175 controls selected from the Chinese Consortium for Prostate Cancer Genetics (ChinaPCa). A logistic regression analysis was used to estimate allelic odds ratios (ORs) of these SNPs for PCa.
RESULTS
Among the 53 SNPs, 50 were polymorphic in the Chinese population. Of which, 10 and 24 SNPs were significantly associated with PCa risk in Chinese men at P < 0.001 and <0.05, respectively. These 24 significant SNPs included 17, 5, and 2 SNPs that were originally discovered in European, Japanese, and Chinese descent, respectively. The estimated ORs ranged from 1.10 to 1.49 and the direction of association was consistent with previous studies. When ORs were estimated separately for PCa with Gleason score ≤7 and ≥8, a marginally significant difference in ORs was found only for two of the 24 SNPs (P = 0.02 and 0.04).
CONCLUSION
About half of PCa risk-associated SNPs identified in GWAS of various populations are associated with PCa risk in Chinese men. Information on PCa risk-associated SNPs and their ORs may facilitate risk assessment of PCa risk in Chinese men.
背景
几项前列腺癌（PCa）的全基因组关联研究（GWAS）已经确定了许多单核苷酸多态性（SNPs），这些 SNPs 与不同种族群体的 PCa 风险显著相关。本研究的目的是评估这些 SNPs 中哪些与中国男性的 PCa 风险相关，并估计它们的关联强度。
方法
评估了来自欧洲、非裔美国人、日本和中国血统的 GWAS 中报道与 PCa 风险相关的所有 SNPs，这些 SNPs 在中国前列腺癌遗传联合体（ChinaPCa）中选择的 1922 例 PCa 病例和 2175 例对照中进行了评估。使用逻辑回归分析来估计这些 SNPs 对 PCa 的等位基因优势比（OR）。
结果
在 53 个 SNP 中，有 50 个在中国人中具有多态性。其中，有 10 个和 24 个 SNP 在中国男性中与 PCa 风险显著相关，P 值均小于 0.001 和 <0.05。这 24 个显著 SNP 包括 17 个、5 个和 2 个最初在欧洲、日本和中国血统中发现的 SNP。估计的 OR 范围为 1.10 至 1.49，其关联方向与之前的研究一致。当分别为 Gleason 评分≤7 和≥8 的 PCa 估计 OR 时，仅在 24 个 SNP 中的两个中发现 OR 存在略微显著差异（P=0.02 和 0.04）。
结论
在不同人群的 GWAS 中确定的与 PCa 风险相关的 SNP 中，约有一半与中国男性的 PCa 风险相关。与 PCa 风险相关的 SNP 及其 OR 的信息可能有助于评估中国男性的 PCa 风险。
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