Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210 (USA) http://mattson.group.chemistry.ohio-state.edu/
Angew Chem Int Ed Engl. 2013 Oct 18;52(43):11317-20. doi: 10.1002/anie.201304921. Epub 2013 Aug 26.
It takes two: A unique organocatalyzed cascade for the unsymmetric double arylation of α-nitrodiazoesters is described. This organocascade features the strategic use of carbene-activating anilines in conjunction with a urea catalyst, thus allowing for the synthesis of pharmaceutically attractive α-diarylesters through a transient NH insertion process.
本文描述了一种独特的有机催化级联反应，用于不对称双芳基化α-硝基重氮酯。这种有机级联反应的特点是战略地使用碳烯激活苯胺与脲催化剂结合，从而允许通过瞬态 NH 插入过程合成具有吸引力的药物的α-二芳基酯。
