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用于将奥沙利铂靶向递送至癌细胞的葫芦[7]脲容器。

Cucurbit[7]uril containers for targeted delivery of oxaliplatin to cancer cells.

作者信息

Cao Liping, Hettiarachchi Gaya, Briken Volker, Isaacs Lyle

机构信息

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA).

出版信息

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12033-7. doi: 10.1002/anie.201305061. Epub 2013 Sep 13.

DOI:10.1002/anie.201305061
PMID:24039074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3954956/
Abstract

: The cucurbit[7]uril derivative which bears a covalently attached biotin targeting ligand allows for the efficient delivery of oxaliplatin as its •oxaliplatin complex to cancer cells resulting in enhanced cytotoxicity relative to oxaliplatin alone.

摘要

带有共价连接的生物素靶向配体的葫芦[7]脲衍生物能够将作为其•奥沙利铂配合物的奥沙利铂有效递送至癌细胞，相对于单独使用奥沙利铂，其细胞毒性增强。

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本文引用的文献

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Supramolecular velcro for reversible underwater adhesion.用于可逆水下粘附的超分子维可牢尼龙搭扣
Angew Chem Int Ed Engl. 2013 Mar 11;52(11):3140-4. doi: 10.1002/anie.201209382. Epub 2013 Feb 4.
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Supramolecular sensor for cancer-associated nitrosamines.用于检测癌症相关亚硝胺的超分子传感器。
J Am Chem Soc. 2012 Dec 12;134(49):20021-4. doi: 10.1021/ja3102192. Epub 2012 Dec 4.
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Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril.葫芦[ n ]脲增强原发性多形性胶质母细胞瘤细胞中替莫唑胺的稳定性和活性。
Chem Commun (Camb). 2012 Oct 11;48(79):9843-5. doi: 10.1039/c2cc35131e. Epub 2012 Aug 30.
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Supramolecular polymeric hydrogels.超分子聚合物水凝胶。
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Release of high-energy water as an essential driving force for the high-affinity binding of cucurbit[n]urils.高能水的释放是瓜环高亲和力结合的必要驱动力。
J Am Chem Soc. 2012 Sep 19;134(37):15318-23. doi: 10.1021/ja303309e. Epub 2012 Sep 10.
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Synthesis and self-assembly processes of monofunctionalized cucurbit[7]uril.单官能化葫芦脲的合成及自组装过程。
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