Yin Tuanfang, Huang Fengying, Ren Jihao, Liu Wei, Chen Xing, Li Lihua, Xie Dinghua, Lu Yongde
Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China, 410011.
Int J Clin Exp Med. 2013 Sep 1;6(8):720-3. eCollection 2013.
Sudden sensorineural hearing loss (SSNHL) is usually unilateral and can be associated with tinnitus and vertigo. The most common causes of this disease are known to be the vascular and viral agents, but immune disorders are involved in the development of sudden deafness. The antiphospholipid syndrome (APS) is an acquired autoimmune system disorder, which is defined as the presence of antiphospholipid antibodies (APA) in the patient's blood, then cause venous and/or arterial thrombosis in various organs of the body, for example, thrombosis can occur in the placenta and/or the inner ear. As a result, it can cause abortion and/or sudden deafness. Bilateral SSNHL following habitual abortion is a rare clinical event. Here, we report a case of 32-year-old woman who presented with bilateral sudden hearing loss following recurrent pregnancy loss (RPL) as the first manifestation of primary antiphospholipid syndrome. Combine the literature, the diagnosis, clinical implication and treatment are discussed.
突发性感音神经性听力损失（SSNHL）通常为单侧性，可伴有耳鸣和眩晕。已知该疾病最常见的病因是血管性和病毒性因素，但免疫紊乱也参与了突发性耳聋的发病过程。抗磷脂综合征（APS）是一种后天获得性自身免疫系统疾病，其定义为患者血液中存在抗磷脂抗体（APA），进而导致身体各个器官发生静脉和/或动脉血栓形成，例如，血栓可发生在胎盘和/或内耳。因此，它可导致流产和/或突发性耳聋。习惯性流产后出现双侧SSNHL是一种罕见的临床情况。在此，我们报告一例32岁女性，其以复发性流产（RPL）后双侧突发性听力损失作为原发性抗磷脂综合征的首发表现。结合文献，对其诊断、临床意义及治疗进行了讨论。
