Cai Jian, Ye Meirong, Fei Chunhua, Xu Feng
Fengxian Mental Health Center Shanghai, China.
Int J Clin Exp Med. 2013 Sep 1;6(8):724-6. eCollection 2013.
The choice of the generic drug is reasonable if there is evidence for its therapeutic equivalence with the brand-name drug. However, the reduced effectiveness of switching from brand-name drug to generic drug is not rare. The impact of brand-name worship and expectation psychology on drug efficacy is noteworthy to report. A 45-year-old woman suffered from depression mood disorder. She experienced profound improvement in her depressive symptoms after a switch from domestic generic venlafaxine to imported brand-name counterpart. The interview showed that the woman has a strong brand-name drug worship and expectation psychology, which is representative, typical and popular in China especially in vast rural areas. Medication education does not work too much. The brand-name drug worship and expectation psychology might improve drug efficacy when patient is switched from generic drug to branded medication.
如果有证据表明仿制药与品牌药具有治疗等效性，那么选择仿制药是合理的。然而，从品牌药转换为仿制药后疗效降低的情况并不罕见。值得报告的是，品牌崇拜和期望心理对药物疗效的影响。一名45岁的女性患有抑郁情绪障碍。在从国产仿制药文拉法辛转换为进口品牌药后，她的抑郁症状有了显著改善。访谈显示，这名女性有强烈的品牌药崇拜和期望心理，这在中国尤其是广大农村地区具有代表性、典型性且普遍存在。药物教育作用不大。当患者从仿制药转换为品牌药时，品牌崇拜和期望心理可能会提高药物疗效。
