人类胚胎滞育：是时候考虑了吗？
Embryonic diapause in humans: time to consider?
作者信息
Ptak Grazyna E, Modlinski Jacek A, Loi Pasqualino
机构信息
Department of Comparative Biomedical Sciences, University of Teramo, Piazza A, Moro, Teramo 64100, Italy.
出版信息
Reprod Biol Endocrinol. 2013 Sep 17;11:92. doi: 10.1186/1477-7827-11-92.
BACKGROUND
When a competent blastocyst stage embryo finds itself in an unreceptive uterus, it delays development. In around one hundred species representing various orders, this delay is known to be reversible, but this phenomenon - termed embryonic diapause (ED) - is not considered a general characteristic of all mammals.
PRESENTATION OF THE HYPOTHESIS
Recently, however, we demonstrated that a non-diapausing species, the sheep, is capable of ED, suggesting the hypothesis that this is in fact an ancestral trait common to all mammals, including humans.
TESTING THE HYPOTHESIS
In spite of the obvious difficulties in testing this idea, we propose a combination of indirect observations on human fertility patients, and direct study of the embryos of non-human primates.
IMPLICATIONS OF THE HYPOTHESIS
Support for our hypothesis would require revision of obstetric interventions routinely performed when a human pregnancy extends beyond the due date.
背景
当一个发育正常的囊胚期胚胎处于未着床的子宫中时，其发育会延迟。在代表不同目类的大约100个物种中，这种延迟是可逆的，但这种现象——称为胚胎滞育（ED）——并不被认为是所有哺乳动物的普遍特征。
假说的提出
然而，最近我们证明，一个不发生滞育的物种——绵羊，能够发生胚胎滞育，这表明该假说，即这实际上是包括人类在内的所有哺乳动物共有的祖先特征。
对假说的验证
尽管验证这一观点存在明显困难，但我们建议结合对人类生育患者的间接观察以及对非人类灵长类动物胚胎的直接研究。
假说的意义
若我们的假说得到支持，则需要对人类妊娠超过预产期时常规进行的产科干预措施进行修订。
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