Möller H-J, Seemüller F, Schennach-Wolff R, Stübner S, Rüther E, Grohmann R
Department of Psychiatry and Psychotherapy,Ludwig-Maximilians-University,Nussbaumstr.7, 80336 Munich,Germany.
Bezirkskrankenhaus Augsburg, Dr-Mack-Straße 1, 86156Augsburg.
Int J Neuropsychopharmacol. 2014 Jul;17(7):983-96. doi: 10.1017/S1461145713000837. Epub 2013 Sep 18.
Based on a careful literature search a review is presented of the history, background, concepts and current use of comedication and polypharmacy in psychiatry. The pros and cons of comedication and polypharmacy are presented, as well as their apparent increase in recent times. Possible reasons for the increase of comedication/polypharmacy are described. Both the potential advantages as well as the potential risks are discussed. The one sided view that all comedication/polypharmacy is nothing but problematic is questioned. Comedication/polypharmacy seems to be, among others, the current answer to the well-known limited efficacy and effectiveness of current monotherapy treatment strategies.
基于全面的文献检索，本文对精神科联合用药和多药联合使用的历史、背景、概念及当前应用进行了综述。阐述了联合用药和多药联合使用的利弊，以及近年来其明显增多的情况。描述了联合用药/多药联合使用增加的可能原因。讨论了潜在的益处和潜在风险。对认为所有联合用药/多药联合使用都存在问题的片面观点提出了质疑。联合用药/多药联合使用似乎是，其中包括，对当前单一疗法治疗策略众所周知的有限疗效的当前应对方法。
