Marcus D M, Shore J W, Albert D M
David G. Cogan Eye Pathology Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston.
Arch Ophthalmol. 1990 Jan;108(1):96-100. doi: 10.1001/archopht.1990.01070030102038.
We examined an orbital exenteration specimen from an anophthalmic patient with focal dermal hypoplasia. Eyelid angiofibromas were evident and immunoperoxidase studies for human papilloma virus were negative. Orbital tissue contained a ductal cyst, chronic inflammation of the lacrimal duct and sac, rudimentary conjunctival fornices, lacrimal gland, striated muscle, and adipose tissue. Microscopic examination revealed a posteriorly located cystic structure with uveal and lens remnants. Neuroectodermal structures consistent with retina, optic nerve, or meninges were not observed, thus representing true anophthalmia. These findings remain as the only histopathologic description of ocular tissues in patients with focal dermal hypoplasia.
我们检查了一名患有局灶性皮肤发育不全的无眼患者的眼眶内容剜出标本。眼睑血管纤维瘤明显，人乳头瘤病毒免疫过氧化物酶研究呈阴性。眼眶组织包含一个导管囊肿、泪道和泪囊的慢性炎症、结膜穹窿残迹、泪腺、横纹肌和脂肪组织。显微镜检查显示一个位于后方的囊性结构，伴有葡萄膜和晶状体残余物。未观察到与视网膜、视神经或脑膜一致的神经外胚层结构，因此代表真正的无眼。这些发现仍然是局灶性皮肤发育不全患者眼部组织的唯一组织病理学描述。
