Greer R O, Reissner M W
Division of Oral Pathology and Oncology, University of Colorado School of Dentistry, Denver.
J Periodontol. 1989 Jun;60(6):330-5. doi: 10.1902/jop.1989.60.6.330.
Focal dermal hypoplasia syndrome (FDH) is a congenital disorder of mesodermal derivation with some ectodermal participation. The disorder, first described in 1962, is characterized by tenacious defects consisting of thinning of the skin; herniations of adipose tissue; abnormal skin pigmentation and other skeletal, dental, ocular, hair, and nail abnormalities. A rare instance of focal dermal hypoplasia syndrome is reported as characterized by papillary gingival hyperplasia. Differential diagnostic guidelines that separate focal dermal hypoplasia from a host of other skin and mucous membrane disorders are discussed along with therapeutic modalities and the possible relationship of human papillomavirus to focal dermal hypoplasia syndrome.
局灶性真皮发育不全综合征（FDH）是一种起源于中胚层并伴有外胚层部分参与的先天性疾病。该疾病于1962年首次被描述，其特征为包括皮肤变薄、脂肪组织疝出、皮肤色素沉着异常以及其他骨骼、牙齿、眼部、毛发和指甲异常在内的顽固性缺陷。本文报道了一例罕见的以乳头牙龈增生为特征的局灶性真皮发育不全综合征。文中讨论了将局灶性真皮发育不全与一系列其他皮肤和黏膜疾病区分开来的鉴别诊断指南，以及治疗方法和人乳头瘤病毒与局灶性真皮发育不全综合征之间可能的关系。
