Laboratory of Nutrition and Metabolism, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil; Department of Physical Education, Institute of Physical Education and Sport, State University of Londrina, Campus Universitário, Londrina, Paraná, Brazil.
Nutrition. 2013 Nov-Dec;29(11-12):1326-30. doi: 10.1016/j.nut.2013.04.017. Epub 2013 Sep 14.
Lipodystrophy syndrome is an unexpected clinical manifestation in patients infected with HIV and might be a clinical marker of increased risk for cardiovascular diseases (CVDs). Because hyperhomocysteinemia has been associated with CVD, the goal of the present study was to investigate homocysteine (Hcy) levels and their association with the factors of lipodystrophy syndrome in men with HIV.
Hcy metabolism-related molecules were determined in 13 men infected with HIV with lipodystrophy (HIV+LIP), 10 men with HIV without lipodystrophy (HIV), and 10 healthy controls (C).
Significant (P < 0.05) increased Hcy plasma levels were found in HIV (20.5%) and in HIV+LIP (35.2%) compared with the control group. Plasma levels of vitamin B12 (HIV, 26.5%; HIV+LIP, 28.8%) and folate (HIV, 39.1% and HIV+LIP, 49.4%) were significantly (P < 0.05) lower in the two groups of HIV patients compared with control. HIV+LIP men presented raised plasma total sulfur-containing amino acids (20.1%) and lower total plasma thiol (11.3%) than controls. The same was not observed in the HIV group. Spearman's correlation test revealed significant (P < 0.05) association between plasma Hcy and duration of highly active antiretroviral therapy (HAART) and plasma insulin, as well as plasma adiponectin levels.
Our results demonstrated that HIV+LIP men were more susceptible to disturbances in Hcy metabolism compared with men infected with HIV without lipodystrophy characteristics. Duration of HAART treatment, elevated plasma insulin, and low levels of adiponectin seem to be relevant for the appearance of these Hcy metabolic disorders.
脂肪营养不良综合征是感染 HIV 的患者出现的一种意外临床表现，可能是心血管疾病（CVD）风险增加的临床标志物。由于高同型半胱氨酸血症与 CVD 相关，本研究旨在调查 HIV 男性患者同型半胱氨酸（Hcy）水平及其与脂肪营养不良综合征相关因素的关系。
测定了 13 名脂肪营养不良的 HIV 感染男性（HIV+LIP）、10 名无脂肪营养不良的 HIV 感染男性（HIV）和 10 名健康对照者（C）的 Hcy 代谢相关分子。
与对照组相比，HIV（20.5%）和 HIV+LIP（35.2%）患者的 Hcy 血浆水平显著升高（P<0.05）。两组 HIV 患者的维生素 B12 （HIV，26.5%；HIV+LIP，28.8%）和叶酸（HIV，39.1%和 HIV+LIP，49.4%）血浆水平显著降低（P<0.05）。与对照组相比，HIV+LIP 男性的血浆总含硫氨基酸（20.1%）升高，而总血浆巯基（11.3%）降低。HIV 组未观察到这种情况。Spearman 相关检验显示，Hcy 与高效抗逆转录病毒治疗（HAART）和血浆胰岛素的时间以及血浆脂联素水平之间存在显著（P<0.05）相关性。
我们的结果表明，与无脂肪营养不良特征的 HIV 感染男性相比，HIV+LIP 男性更易发生 Hcy 代谢紊乱。HAART 治疗时间、血浆胰岛素升高和脂联素水平降低似乎与这些 Hcy 代谢紊乱的出现有关。
