Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Early Hum Dev. 2013 Dec;89(12):1037-40. doi: 10.1016/j.earlhumdev.2013.08.012. Epub 2013 Sep 15.
The relationship between cord arterial pH (CA-pH) > 7.000 and the neonatal outcome is not clear.
To evaluate if asymptomatic infants born with unexpected cord arterial pH (CA-pH) between 7.000 and 7.100 develop clinical, biochemical, and instrumental signs of hypoxic cerebral, renal, and heart failure more frequently than symptomatic infants.
Term infants with CA-pH of 7.000-7.100 and appropriate birth weight were prospectively and consecutively enrolled and classified as asymptomatic, when they had no resuscitation, early respiratory distress or early abnormal neurologic signs, and symptomatic infants. Clinical, biochemical, and instrumental signs of hypoxic cerebral, renal, and heart failure were evaluated in the two groups.
A total of 53 infants were enrolled. Twenty-eight (53%) were asymptomatic. CA-pH was similar in both the groups, while the cTnI serum concentration in the first day of life and the occurrence of poor feeding were higher in the symptomatic than in asymptomatic infants. An arterial lactate level of ≥ 4.1 mmol/l measured in the first hour of life was an independent risk factor for the development of a symptomatic course.
In our population the majority of infants born with a CA-pH between 7.000 and 7.100 were asymptomatic and would not have needed immediate admission to the neonatal care unit. Symptomatic infants showed a higher occurrence of subclinical heart injury and poor feeding.
脐带动脉血 pH 值（CA-pH）>7.000 与新生儿结局之间的关系尚不清楚。
评估出生时 CA-pH 值在 7.000 至 7.100 之间的无症状婴儿与有症状婴儿相比，是否更频繁地出现缺氧性脑、肾和心力衰竭的临床、生化和仪器检查的征象。
前瞻性连续纳入 CA-pH 值为 7.000-7.100 且出生体重适当的足月婴儿，并根据是否需要复苏、早期呼吸窘迫或早期异常神经体征进行无症状和有症状分类。评估两组婴儿缺氧性脑、肾和心力衰竭的临床、生化和仪器检查的征象。
共纳入 53 例婴儿。28 例（53%）为无症状。两组的 CA-pH 值相似，而有症状婴儿的肌钙蛋白 I 血清浓度在生命的第一天和喂养不良的发生率更高。生后 1 小时内动脉血乳酸水平≥4.1mmol/L 是发生有症状病程的独立危险因素。
在我们的人群中，大多数出生时 CA-pH 值在 7.000 至 7.100 之间的婴儿为无症状，不需要立即入住新生儿重症监护病房。有症状婴儿表现出更高的亚临床心脏损伤和喂养不良发生率。
