影响胃癌转移性淋巴结摄取18F-FDG的因素。

Factors affecting 18F-FDG uptake by metastatic lymph nodes in gastric cancer.

作者信息

Kim Young Hwan, Choi Joon Young, Do In-Gu, Kim Sung, Kim Byung-Tae

机构信息

*From the Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; †Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri; and Departments of ‡Pathology and §Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.†Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri; and Departments of ‡Pathology and § Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

J Comput Assist Tomogr. 2013 Sep-Oct;37(5):815-9. doi: 10.1097/RCT.0b013e3182972989.

DOI:10.1097/RCT.0b013e3182972989

PMID:24045262

Abstract

OBJECTIVE

We assessed factors affecting fluorine F 18 fluorodeoxyglucose (F-FDG) uptake of metastatic lymph nodes (LNs) in advanced gastric cancer (AGC) due to low F-FDG uptake of metastatic LNs in gastric cancer.

METHODS

Retrospective analyses were performed on 31 patients with AGCs who underwent preoperative F-FDG positron emission tomography (PET) and subsequent gastrectomy. Metastatic LNs were compared with primary tumors (on a one-to-one basis) with respect to maximum standardized uptake values, glucose transporter type 1 (GLUT-1) expression, proliferation indices (using Ki-67), microvessel density, and lymphatic vessel density.

RESULTS

Maximum standardized uptake values of metastatic LNs were significantly correlated with % GLUT-1 expression (ρ = 0.80, P < 0.0001) and Ki-67 labeling index (ρ = 0.57, P = 0.001) in LNs. These uptake values were also significantly correlated with SUVs (ρ = 0.54; P = 0.002), % GLUT-1 expression (ρ = 0.71, P < 0.0001), and Ki-67 labeling index (ρ = 0.43, P = 0.019) in primary tumors. In multiple regression analysis, only % GLUT-1 expression in primary tumors and metastatic LNs were significant factors in predicting maximum standardized uptake value of metastatic LNs.

CONCLUSIONS

In AGCs, GLUT-1 expression and Ki-67 labeling index are important factors in predicting F-FDG uptake by metastatic LNs.

摘要

目的

由于胃癌转移淋巴结的氟代脱氧葡萄糖（F-FDG）摄取较低，我们评估了影响晚期胃癌（AGC）转移淋巴结F-FDG摄取的因素。

方法

对31例行术前F-FDG正电子发射断层扫描（PET）及随后胃切除术的AGC患者进行回顾性分析。将转移淋巴结与原发肿瘤（一对一）在最大标准化摄取值、葡萄糖转运蛋白1型（GLUT-1）表达、增殖指数（使用Ki-67）、微血管密度和淋巴管密度方面进行比较。

结果

转移淋巴结的最大标准化摄取值与淋巴结中GLUT-1表达百分比（ρ = 0.80，P < 0.0001）和Ki-67标记指数（ρ = 0.57，P = 0.001）显著相关。这些摄取值还与原发肿瘤中的SUV（ρ = 0.54；P = 0.002）、GLUT-1表达百分比（ρ = 0.71，P < 0.0001）和Ki-67标记指数（ρ = 0.43，P = 0.019）显著相关。在多元回归分析中，仅原发肿瘤和转移淋巴结中的GLUT-1表达百分比是预测转移淋巴结最大标准化摄取值的重要因素。