基于金的抗癌药物的作用模式：结构视角。
The mode of action of anticancer gold-based drugs: a structural perspective.
机构信息
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
出版信息
Chem Commun (Camb). 2013 Oct 3;49(86):10100-2. doi: 10.1039/c3cc46400h.
PMID:24045294
Abstract
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
摘要
通过 X 射线晶体学研究了几种代表性的基于金的药物与鸡卵清白溶菌酶之间的相互作用。为三种金属药物 - 蛋白质加合物解析的高分辨率晶体结构提供了有价值的见解，深入了解了这些有前途的金属化合物的分子机制以及固有蛋白质金属化过程。
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