Department of Chemistry "Ugo Schiff", Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
Metallomics. 2014 Feb;6(2):233-6. doi: 10.1039/c3mt00265a.
The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
本文通过 X 射线衍射和 ESI 质谱研究了双核金(III)配合物 Auoxo6 与模型蛋白牛胰腺核糖核酸酶的反应。数据提供了加合物形成和酶抑制过程的线索，并间接地提供了这种金属药物可能作用模式的线索。
