多灶性浸润性乳腺癌的 HER2 检测：需要多少个切片？
HER2 testing of multifocal invasive breast carcinoma: how many blocks are enough?
机构信息
Dept of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, 6-500, Toronto, ON M5G 1X5, Canada; e-mail:
出版信息
Am J Clin Pathol. 2013 Oct;140(4):588-92. doi: 10.1309/AJCPZSV2W1CPGRJW.
OBJECTIVES
To determine the diagnostic yield of testing multiple blocks for HER2 in cases of multifocal breast carcinoma.
METHODS
We identified 246 consecutive cases of multifocal invasive breast carcinoma in which HER2 was tested on more than 1 tumor focus. We performed an audit of all cases with respect to tumor size, grade, and histologic type.
RESULTS
HER2 status was concordant between multiple foci in 230 (93.5%) of 246 cases, with the largest focus having the most positive HER2 result in 242 (98.4%) of 246 cases. We did not find a single case in which a smaller focus demonstrated a more positive HER2 status unless this focus was either higher grade or different histologically.
CONCLUSIONS
Our findings support the evaluation of HER2 on the largest focus, with additional testing on smaller foci having a different histologic type or higher grade.
目的
确定在多灶性乳腺癌病例中检测 HER2 的多个肿瘤块的诊断收益。
方法
我们鉴定了 246 例连续的多灶性浸润性乳腺癌病例，这些病例中 HER2 在超过 1 个肿瘤焦点上进行了检测。我们对所有病例的肿瘤大小、分级和组织学类型进行了审核。
结果
246 例中有 230 例（93.5%）多个焦点的 HER2 状态一致，246 例中有 242 例（98.4%）最大焦点的 HER2 结果最阳性。我们没有发现一个较小焦点表现出更阳性的 HER2 状态的单一病例，除非这个焦点的分级更高或组织学不同。
结论
我们的研究结果支持对最大焦点进行 HER2 评估，对具有不同组织学类型或更高分级的较小焦点进行额外检测。
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