1] Department of Medical Oncology, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, Marseille 13009, France [2] Unité de Recherche Contre le Cancer, CRCM-INSERM U1068, Faculté de Luminy, Université Aix-Marseille, Marseille 13009, France.
Br J Cancer. 2013 Oct 1;109(7):1750-4. doi: 10.1038/bjc.2013.516. Epub 2013 Sep 17.
Sunitinib is a tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC). Few data evaluated severe buccodental adverse events. The aim of this study was to evaluate sunitinib buccodental toxicity in patients with metastatic RCC and to compare it with that of standard chemotherapy in patients with other solid cancers.
Patients with RCC treated with sunitinib and patients with other solid tumours treated with chemotherapy were followed for 3 months. Data on dental appliances, oral hygiene/care practices before and during treatment were collected.
A total of 116 patients were included (58 RCC treated by sunitinib: group S, and 58 treated by chemotherapy: group C). No differences in dental care habits were noted before treatment. In group S, patients reported significantly more frequent pain (P<0.01), teeth instability (P=0.01), gingival bleeding (P=0.01) and change in teeth colour (P=0.02). In all, 58% of patients in this group had to modify their diet (P<0.01). Frequency of dentist visits for teeth removal was increased (25% vs 8%, P=0.01).
Sunitinib seems to increase buccodental toxicity as compared with chemotherapy. This finding emphasises the need for optimal dental care and standardised dental follow-up in patients treated with sunitinib.
舒尼替尼是一种酪氨酸激酶抑制剂，已被批准用于治疗肾细胞癌（RCC）。很少有数据评估严重的口腔牙科不良事件。本研究的目的是评估转移性 RCC 患者接受舒尼替尼治疗的口腔牙科毒性，并将其与其他实体瘤患者接受标准化疗的毒性进行比较。
对接受舒尼替尼治疗的 RCC 患者和接受化疗的其他实体瘤患者进行了 3 个月的随访。收集了治疗前后口腔器械、口腔卫生/护理习惯的数据。
共纳入 116 例患者（58 例 RCC 患者接受舒尼替尼治疗：S 组，58 例接受化疗：C 组）。治疗前两组的口腔护理习惯无差异。在 S 组中，患者报告的疼痛（P<0.01）、牙齿不稳定（P=0.01）、牙龈出血（P=0.01）和牙齿颜色改变（P=0.02）更为频繁。在该组中，有 58%的患者不得不改变饮食（P<0.01）。因牙齿脱落而就诊的频率增加（25% vs 8%，P=0.01）。
与化疗相比，舒尼替尼似乎会增加口腔牙科毒性。这一发现强调了在接受舒尼替尼治疗的患者中，需要进行最佳的口腔护理和标准化的牙科随访。
