Order S E, Sleeper A M, Stillwagon G B, Klein J L, Leichner P K
Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, Maryland 21205.
Cancer Res. 1990 Feb 1;50(3 Suppl):1011s-1013s.
Radiolabeled antibodies are analyzed from the classical approach in radiation oncology being compared to geometric isotopic implants, external radiation, and tumor-dose response and energy of the isotope used for cytotoxicity. In addition, physiological factors that limit antibody uptake, varied routes of administration, toxicity of treatment, as well as present clinical progress are reviewed.
将放射性标记抗体与几何同位素植入、外照射、肿瘤剂量反应以及用于细胞毒性的同位素能量进行比较，采用放射肿瘤学的经典方法对其进行分析。此外，还综述了限制抗体摄取的生理因素、不同的给药途径、治疗毒性以及目前的临床进展。
