1. Department of Gastroenterology, Yamagata University School of Medicine, Yamagata, Yamagata 990-9585;
Int J Med Sci. 2013 Sep 9;10(11):1575-7. doi: 10.7150/ijms.6436. eCollection 2013.
Ribavirin is one of the major agents used in combination therapy with interferon for chronic hepatitis C, but is often associated with hemolytic anemia as a serious adverse event. Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. Our findings suggest that hemolysis associated with ribavirin is triggered by an energy crisis and consequent oxidative stress, thus having implications for the prevention of such hemolysis.
利巴韦林是慢性丙型肝炎联合干扰素治疗的主要药物之一，但常伴有溶血性贫血等严重不良反应。采用代谢组学分析方法，我们发现利巴韦林治疗后患者红细胞中糖酵解和磷酸戊糖途径产生的中间代谢产物浓度显著降低。我们的研究结果提示，利巴韦林相关性溶血是由能量危机和随后的氧化应激引发的，因此对预防此类溶血具有重要意义。
