Dakovic D, Colic M, Cakic S, Mileusnic I, Hajdukovic Z, Stamatovic N
Clinic of Dental Medicine, Military Medical Academy, Belgrade, Serbia.
J Clin Pediatr Dent. 2013 Summer;37(4):377-80. doi: 10.17796/jcpd.37.4.l135531h4542gj66.
The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established.
Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study.
The Salivary IL-8 level was statistically significantly (p < 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p > 0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found.
An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.
本研究旨在调查伴有（DM+P）或不伴有（DM-P）牙周炎的1型糖尿病（DM）患者与健康受试者唾液中白细胞介素-8（IL-8）水平的差异。还建立了这些细胞因子水平与临床牙周参数之间的相关性。
招募20名1型糖尿病儿童和青少年（10名诊断为牙周炎，10名无牙周炎迹象）以及由20名7-18岁健康儿童和青少年组成的对照组进行本研究。
与非糖尿病对照组（101.99±68.32）相比，1型糖尿病患者（474.47±716.76）的唾液IL-8水平在统计学上显著升高（p<0.005）。伴有牙周炎的1型糖尿病患者与无牙周炎的糖尿病患者相比，唾液IL-8水平无差异（p>0.05）。当1型糖尿病患者的唾液IL-8水平与临床参数相关时，未发现统计学意义。
不伴有牙周炎的1型糖尿病患者唾液IL-8水平升高在糖尿病微血管和大血管病变的发展以及动脉粥样硬化的发病机制中起主要作用。因此，这可能为评估糖尿病并发症的风险、预防和治疗提供依据。
